CalliSphere载药微球与碘油介入栓塞治疗转移性肝癌后骨髓毒性及生活质量对比研究  

Comparison of Myelosuppression and Quality Scores of Life After Interventional Chemoembolization with CalliSphere Drug-loaded Microspheres and Iodine Oil for Metastatic Liver Cancer

作　　者：周怡婷 郭晶晶 刘昌贺 吴清华 顾琛 吴震海 ZHOU Yi-ting;GUO Jing-jing;LIU Chang-he;WU Qing-hua;GU Ghen;WU Zheng-hai(Interventional Department,The Afiliated Hospital of Jiangnan University,Wuxi,Jiangsu,214062,China)

机构地区：[1]江南大学附属医院介入科,江苏无锡214062

出　　处：《中国血液流变学杂志》2019年第4期437-441,F0003,共6页Chinese Journal of Hemorheology

基　　金：无锡市卫计委重大项目(ZD201711);无锡市卫生局科研面上项目(MS20151);无锡市科技发展指导性计划(CSZON1710);无锡市医学重点人才培养对象项目(ZDRCPY010)。

摘　　要：目的比较CalliSphere载药微球与碘油介入化疗栓塞治疗转移性肝癌后骨髓抑制情况.方法回顾性分析2016年4月-2019年9月转移性肝癌患者58例,按照不同栓塞材料分为两组,一组为CalliSphere载药微球栓塞组(载药组)30例,另一组为普通碘化油栓塞组(碘油组)28例.根据WHO骨髓抑制程度分级标准,评定两组患者化疗前后骨髓抑制程度及白细胞、血红蛋白、血小板、中性粒细胞数值情况.观察两组患者治疗前后生活质量评分(QOL)及卡氏评分(KPS)情况.结果两组患者的基线资料之间差异无统计学意义(P均>0.05),具有可比性.碘油组术后白细胞、血红蛋白及血小板降低差异有统计学意义(P=0.010、0.001、0)、中性粒细胞降低差异无统计学意义(P=0.286);载药组治疗前后的白细胞、血红蛋白、血小板及中性粒细胞变化差异无统计学意义(P=0.608,0.083,0.223,0.099);两组患者治疗前后白细胞和血红蛋白变化差值的差异无统计学意义(P=0.278,0.67),血小板和中性粒细胞差值的差异具有统计学意义(P=0.01,0.01);碘油组治疗后骨髓抑制情况较术前增多,程度较术前加重,差异具有统计学意义(Z=-3.849,P=0.000);两组患者治疗前及治疗后1个月QOL评分差值及KPS评分差值,载药组生活质量改善情况优于碘油组,差异均具有统计学意义(Z=-2.835,-3.242;P=0.001,0.001).结论碘油组治疗后骨髓抑制情况较载药组更常见,程度加重;CalliSphere载药微球治疗对外周血细胞影响不大,在对血小板及中性粒细胞方面影响较碘油组小;载药组患者术后生活质量及功能状态优于碘油组.Objective To compare myelosuppression quality scores of life after interventional chemoembolization with CalliSphere drug-loaded microspheres and iodine oil for metastatic liver cancer.Methods An retrospective collection analysis about 58 metastatic hepatic carcinoma patients treated from April 2016 to September 2019 in the Afiliated Hospital of Jiangnan University was performed.The patients were divided into two groups according to two diferent inteventional methods,including 30 patients with CalliSphere drug-loaded microsphere embolization group(drug-loading group),28 cases of iodized oil embolism group(lipiodol group).According to the WHO cassification criteria for myelosuppression,the degree of myelosuppression and the changes of white blood cells,hemoglobin,platclets and neutrophils were measured before and after chemotherapy.The quality of life(QOL)scores and Karnofsky scores of the two groups before and after treatment were observed.Results There were no sigificant diferences in patient baseline characteristics between the two groups(P all>0.05).The blood samples from the first time(average 5 days after surgery)in the two groups showed that the stistically signifcant reduction of white blood cells,hemoglobin and platelets in the lipiodol group(P=0.010,0.001,0.000)and no statistically significant reduction of neutral granular cell(P=0.286)were measured.There was no statistical sigificance to the changes of white blood cells,hemoglobin,platelets,and neutrophils before and after the treatment of the CalliSphere drug microsphere(P=0.608,0.083,0.223,0.099);There was no statistical significance between the discrepancy number of white blood cells and hemoglobin(P=0.278,0.67).There was statistical significance between the discrepancy number of platelets and neutrophils(P=0.01,0.01).After treatment,the occurence on bone marrow inhibition of the iodine oil group patients was more than preoperative and the degree was more serious than preoperative(Z=-3.849,P=0).The quality of life score and the Karnofsky score of the

关 键 词：CalliSphere载药微球 碘化油 肝动脉化疗栓塞 转移性肝癌 骨髓抑制 

分 类 号：R735.1[医药卫生—肿瘤] R730.5[医药卫生—临床医学]