ER、HER-2在甲状腺乳头状癌中的表达及临床意义  

Expression and Clinical Significance of ER and HER-2 in Papillary Thyroid Cancer

作　　者：任艳鑫[1] 廖曼各 杨洁[1] 王晓莉[2] 李晓江[1] REN Yan-xin;LIAO Man-ge;YANG Jie;WANG Xiao-li;LI Xiao-jiang(Dept.of Head and Neck Surgery,The 3rd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650118,China;Dept.of Radiorherapy,The 3rd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650118,China)

机构地区：[1]昆明医科大学第三附属医院头颈外一科,云南昆明650118 [2]昆明医科大学第三附属医院放疗中心,云南昆明650118

出　　处：《昆明医科大学学报》2020年第7期43-48,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81260312,81960489);云南省卫生健康委员会医学后备人才培养计划(H-201634);云南省万人计划“青年拔尖人才”项目基金(云人社通{2019}206号);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2014FZ037);云南省教育厅科学研究基金项目(2019J1287)。

摘　　要：目的探讨ER、HER-2在甲状腺乳头状癌中的表达及临床意义。方法选取2010年1月至2010年6月昆明医科大学第三附属医院甲状腺乳头状癌患者76例,甲状腺良性肿瘤患者(良性组)19例。采用免疫组织化学方法检测ER、HER-2的表达情况,分析ER、HER-2与临床特征之间的关系。结果(1)ER、HER-2在甲状腺乳头状癌组表达明显高于甲状腺良性肿瘤组(P<0.05);(2)在甲状腺乳头状癌中,ER高表达与肿瘤包膜侵犯相关,而HER-2高表达与淋巴结转移相关(P<0.05);(3)ER、HER-2高表达的甲状腺乳头状癌5a局部复发、转移率增高(15.0%vs 2.1%,13.5%vs 3.2%,P<0.05)。结论ER、HER-2可能促进甲状腺乳头状癌局部复发、转移,针对ER、HER-2的治疗可能降低甲状腺乳头状癌的局部复发、转移。Objective To investigate the expression and clinical significance of ER,HER-2 in papillary thyroid cancer.Methods From January 2010 to June 2010,76 patients with papillary thyroid cancer and 19 patients with benign thyroid tumor(benign group)were selected from the Third Affiliated Hospital of Kunming Medical University.The expression of ER and HER-2 was detected byimmunohistochemistry,and the relationship between ER,HER-2 and clinical features was analyzed based on clinical data.Results(1)The expression of ER and HER-2 in papillary thyroid cancer group were significantly higher than that in benign thyroid tumor group(p<0.05);(2)in papillary thyroid cancer,ER high expression was associated with tumor capsule invasion,while HER-2 high expression was associated with lymph node metastasis(P<0.05);(3)High expression of ER and HER-2 in papillary thyroid carcinoma had increased local recurrence and metastasis rate in 5 years.Conclsions ER and HER-2 may promote the local recurrence and metastasis of thyroid papillary carcinoma.Treatment for ER and HER-2 may reduce the local recurrence and metastasis of thyroid papillary carcinoma.

关 键 词：甲状腺乳头状癌 雌激素受体 人表皮生长因子受体2 

分 类 号：R736.1[医药卫生—肿瘤]