Visfatin基因启动子区域的遗传变异与中国北方汉族人群缺血性卒中发病风险研究  

Lack of association between genetic variations in the visfatin gene promoter region and ischemic stroke in the northern Chinese Han population

作　　者：朱瑞霞[1] 王倩雯 刘旭[1] 何志义[1] ZHU Ruixia;WANG Qianwen;LIU Xu(Department of Neurology,The First Affiliated Hospital of China Medical University,Shenyang 110001, China)

机构地区：[1]中国医科大学附属第一临床医院神经内科,辽宁沈阳110001

出　　处：《中风与神经疾病杂志》2020年第7期633-637,共5页Journal of Apoplexy and Nervous Diseases

摘　　要：目的内脂素(Visfatin)是最近发现的一种与动脉粥样硬化相关的促炎性脂肪分子。本研究探讨中国汉族人群中内脂素rs61330082基因多态性与缺血性脑卒中易感性的关系。方法我们采用聚合酶链反应-连接酶检测反应(PCR-LDR)方法检测368个缺血性脑卒中患者及381个健康对照rs61330082基因分型,统计学方法比较两组间基因型及等位基因分布差异。结果我们发现rs61330082基因型和等位基因频率在病例组与对照组中无明显的统计学差异,在分层分析中,在rs61330082基因型和等位基因频率在男性及女性病例组与对照组中无明显的统计学差异。结论因此,在中国北方汉族人群中Visfatin rs61330082单核苷酸多态性与缺血性卒中的发病风险无关。Objective Visfatin,a newly identified pro-inflammatory adipokine,has been related to atherosclerosis,therefore we explore the association between the visfatin rs61330082 and ischemic stroke risk.The-1535 polymorphism(rs61330082)located in the visfatin gene promoter is reportedly associated with inflammatory related atherosclerosis.Method A total of 368 ischemic stroke patients and 381 healthy controls were enrolled for the study.The rs61330082 polymorphism was genotyped by the polymerase chain reaction-ligase detection reaction(PCR-LDR)sequencing method.Results No significant differences in genotypic and allelic frequencies between ischemic stroke patients and healthy controls were observed even when the OR was adjusted for the clinical variables.We also did not find any significant association from sex subtypes.Conclusion Visfatin rs61330082 polymorphism is not associated with ischemic stroke risk in the northern Chinese Han population.

关 键 词：缺血性卒中 基因多态性 内脂素 

分 类 号：R743[医药卫生—神经病学与精神病学]