Wallenberg综合征的临床差异及相关因素  

Clinical differences and related factors of Wallenberg syndrome

作　　者：高文[1] GAO Wen(Liuzhou People’s Hospita,Liuzhhou 545006,China)

机构地区：[1]柳州市人民医院,广西柳州545006

出　　处：《中风与神经疾病杂志》2020年第7期641-644,共4页Journal of Apoplexy and Nervous Diseases

基　　金：柳州市科技惠民重大专项(2018AF10502)。

摘　　要：目的探索Wallenberg综合征的临床表现差异的原因,为临床工作提供宝贵资料。方法回顾性分析41例Wallenberg综合征患者临床及影像资料。并根据年龄、危险因素及病变血管分组,分析各组患者在临床表现上的差异。结果Wallenberg综合征常见的临床症状、体征以眩晕与头晕最多见,其次为构音障碍,小脑性共济失调,感觉障碍,咽反射减弱或消失,吞咽困难,恶心或呕吐,霍纳综合征,眼球震颤。年龄与患者临床症状评分呈负相关(P=0.002)。高血压、糖尿病、高脂血症及吸烟与患者临床表现差异无明显相关。单纯小脑后下动脉病变患者与椎动脉和椎动脉联合小脑后下动脉病变组患者在出现构音障碍(P=0.029)、恶心/呕吐(P=0.033)及吞咽困难(P=0.002)的症状、体征上具有统计学差异。结论Wallenberg综合征临床表现多样;年龄与临床症状越典型程度呈负相关;椎动脉及椎动脉联合小脑后下动脉病变容易导致构音障碍,吞咽困难及恶心/呕吐。Objective To explore the reasons for differences in the clinical manifestations of Wallenberg syndrome,and provid valuable information for clinical work.Methods A retrospective analysis of 41 cases of Wallenberg syndrome clinical and imaging data.Our patients were grouped according to age,risk factors and vascular lesions.The clinical differences were studied in each group of patients.Results The most common clinical symptoms and signs of Wallenberg syndrome was vertigo and dizziness,followed dysarthria,ataxia,sensory disturbances,gag reflex diminished or disappeared,difficulty swallowing,nausea or vomiting,Horner syndrome,nystagmus.Age and clinical symptom scores were negatively correlated(P=0.002).Hypertension,diabetes,hyperlipidemia,and smoking in patients with clinical manifestations were no significant correlation.The vertebral artery and vertebral artery combined cerebellar artery disease patients were statistically significant different with pure posterior inferior cerebellar artery disease patients in the emergence of dysarthria(P=0.029),nausea/vomiting(P=0.033)and dysphagia(P=0.002).Conclusion Clinical manifestations of Wallenberg syndrome are varied.Age and clinical symptom scores were negatively correlated.Vertebral artery and vertebral artery joint cerebellar artery disease more easily lead to dysarthria,dysphagia,and nausea/vomiting.

关 键 词：WALLENBERG综合征 吞咽困难 构音障碍 小脑后下动脉(PICA) 

分 类 号：R743[医药卫生—神经病学与精神病学]