支链氨基酸转氨酶1在上皮性卵巢癌中的表达及临床意义  

Expression of branched-chain amino-acid transaminase 1 in epithelial ovarian cancer and its clinical significance

作　　者：李丹[1] 吴文[1] LI Dan;WU Wen(Department of Gynaecology and Obstetrics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院西院妇产科,武汉430022

出　　处：《临床与病理杂志》2020年第7期1681-1687,共7页Journal of Clinical and Pathological Research

摘　　要：目的:探讨上皮性卵巢癌(epithelial ovarian cancer,EOC)患者癌组织中支链氨基酸转氨酶1(branched-chain amino-acid transaminase 1,BCAT1)的表达及临床意义。方法:采用免疫组织化学法检测133例EOC癌组织中BCAT1表达情况,根据免疫组织化学评分分为BCAT1高表达组(n=41)及低表达组(n=92),卡方检验分析BCAT1的表达与临床病理因素间的关系,Kaplan-Meier生存曲线和对数秩检验比较BCAT1高、低表达组患者无瘤生存率及总生存率的差异,Cox比例风险模型分析影响EOC患者预后的因素。结果:BCAT1表达与宫颈癌国际妇产科联盟(Federation International of Gynecology and Obstetrics, FIGO)分期(P=0.004)、淋巴结转移(P=0.001)显著相关,与糖类抗原125(CA125)水平(P=0.538)、组织学类型(P=0.306)、年龄(P=0.524)、肿瘤大小(P=0.632)、腹水(P=0.178)无显著相关性(P>0.05)。BCAT1高表达组患者1年、3年无瘤生存率及总生存率显著低于BCAT1低表达组(P<0.001)。单因素分析示CA125(P<0.001)、肿瘤大小(P=0.003)、组织学类型(P=0.004)、淋巴结转移(P<0.001)、FIGO分期(P<0.001)和BCAT1表达(P<0.001)是影响EOC患者无瘤生存率的危险因素。多因素分析示FIGO分期(P<0.001)和BCAT1表达(P=0.013)是影响EOC患者无瘤生存率的独立危险因素。单因素分析示FIGO分期(P=0.022)、BCAT1表达(P=0.004)及淋巴结转移(P=0.046)是影响EOC患者总生存率的危险因素;多因素分析示FIGO分期(P<0.001)和BCAT1表达(P=0.025)是影响EOC患者总生存率的独立危险因素。结论:EOC癌组织中BACT1高表达,且与FIGO分期、淋巴结转移和预后显著相关,是影响EOC患者预后的分子标志物。Objective:To investigate the expression of branched-chain amino-acid transaminase 1(BCAT1)in cancer tissues of patients with epithelial ovarian cancer and its clinical significance.Methods:Immunohistochemical method was used to detect the expression of BCAT1 in 133 cases of epithelial ovarian cancer.The epithelial ovarian cancer was divided into 2 groups according to the immunohistochemical score(high expression of BCAT1:n=41;low expression of BCAT1:n=92).Chi-square test was used to analyze the relationship between BCAT1 expression and clinicopathological factors.Kaplan-Meier survival curve and logarithmic rank test were used to compare the difference of disease-free survival rate and overall survival rate between high and low BCAT1 expression groups.Cox proportional hazard model was used to analyze the prognostic factors of EOC patients.Results:BCAT1 expression was significantly correlated with FIGO stage(P=0.004),lymph node metastasis(P=0.001),but not with CA125 level(P=0.538),histological type(P=0.306),age(P=0.524),tumor size(P=0.632),and ascites(P=0.178).The 1-year and 3-year disease-free survival rate and overall survival rate of BCAT1 high expression group were significantly lower than those of BCAT1 low expression group(P<0.001).Univariate analysis showed that CA125(P<0.001),tumor size(P=0.003),histological type(P=0.004),lymph node metastasis(P<0.001),FIGO staging(P<0.001)and BCAT1 expression(P<0.001)were risk factors for the survival rate of EOC patients.Multivariate analysis showed that FIGO staging(P<0.001)and BCAT1 expression(P=0.013)were independent risk factors for EOC patients’disease-free survival.Univariate analysis showed that FIGO staging(P=0.022),BCAT1 expression(P=0.004)and lymph node metastasis(P=0.046)were risk factors affecting the overall survival rate of EOC patients.Multivariate analysis showed that FIGO staging(P<0.001)and BCAT1 expression(P=0.025)were independent risk factors for the overall survival rate of EOC patients.Conclusion:BACT1 is highly expressed in EOC cancer tissues,whic

关 键 词：上皮性卵巢癌 支链氨基酸转氨酶1 临床意义 

分 类 号：R737.31[医药卫生—肿瘤]