microRNA通过ROS途径对脑胶质瘤调节机制的研究进展  

Advances of research in microRNA regulating reactive oxygen species in glioma

作　　者：李晶[1] 崔宏伟[2] 杨凌[2] LI Jing;CUI Hong-wei;YANG Ling(Department of General Medicine;Clinical Medical Research Center, the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院全科医学科,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院临床医学研究中心,内蒙古呼和浩特010050

出　　处：《基础医学与临床》2020年第8期1124-1129,共6页Basic and Clinical Medicine

基　　金：国家自然科学基金(31960153);内蒙古自治区自然科学基金(2017MS0894,2018MS08076);内蒙古自治区卫生计生委医疗卫生计生科研计划项目(201703104)。

摘　　要：microRNA(miRNA)是一种小的非编码RNA,它可以导致靶基因的mRNA降解或翻译抑制。活性氧(ROS)是氧化还原的主要活性产物,在生物体内ROS涉及多种信号通路来调控细胞内环境稳态,细胞中ROS水平失调与肿瘤的发生发展密切相关。在人脑胶质瘤的发生和发展过程中,miRNA和ROS分别可以影响细胞增殖、凋亡、侵袭、迁移和放疗和化疗敏感性,并且miRNA也参与了ROS的调控作用。所以,了解miRNA对ROS的作用机制有助于为脑胶质瘤制定新的治疗策略。The microRNA is a kind of small non-coding RNA,which can cause target mRNA degradation or translation inhibition.Reactive oxygen species(ROS)represent the main active product of redox.It has been reported that ROS are involved in different signaling pathways to keep cell stability.The imbalance of ROS in cell is closely related to tumorigenesis.In the progress of occurrence and development of human glioma,microRNAs and ROS can affect cell proliferation,apoptosis,invasion,migration,and resistance to chemotherapy as well as radiotherapy.Therefore,to understand the mechanism of miRNA on ROS may lead to a potential strategy for glioma treatment.

关 键 词：脑胶质瘤 MICRORNA 活性氧 胶质瘤干细胞 

分 类 号：R739.41[医药卫生—肿瘤]