紫杉醇脂质体联合顺铂通过PI3K/AKT信号通路对不同化疗途径治疗宫颈癌的疗效及安全性  

The efficacy and safety of paclitaxel liposome combined with cisplatin via PI3 K/Akt signaling pathway in the treatment of cervical cancer

作　　者：刘忠 周晓明 张永妍 Liu Zhong

机构地区：[1]宁波大学附属医院,315100

出　　处：《浙江临床医学》2020年第7期936-938,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省宁波市科技计划项目(2019C50095)。

摘　　要：目的探讨紫杉醇脂质体联合顺铂通过PI3K/AKT信号通路对不同化疗途径治疗宫颈癌的疗效及安全性.方法选择宫颈癌患者64例,根据化疗途径随机分为两组,静脉滴注为对照组,动脉灌注为观察组,取宫颈癌组织及对应癌旁组织,采用qRT-PCR和western blotting检测PI3K、AKT、p-PI3K和p-AKT mRNA及蛋白的表达,术后患者继续进行化疗2个疗程,比较两组患者的临床疗效和安全性.结果与癌旁组织比较,对照组和观察组癌组织中PI3K、AKT mRNA表达水平升高(P<0.05),但观察组中mRNA表达水平低于对照组(P<0.05).与癌旁组织比较,对照组和观察组的癌组织中PI3K、AKT、p-PI3K和p-AKT蛋白的表达水平升高(P<0.05),但观察组中蛋白表达水平低于对照组(P<0.05).观察组宫颈癌患者有效缓解率优于对照组(P<0.05),及宫颈癌癌旁浸润和淋巴结转移低于对照组(P<0.05).观察组宫颈癌患者安全性显著高于对照组(P<0.05).结论PI3K/AKT信号通路有望成为治疗宫颈癌的新靶标,以动脉灌注作为化疗途径可以显著提高宫颈癌临床疗效和安全性,减少不良反应.Objective To stinly the effect of paclitaxcl liposome combined with risphtin on the efficacy and safety of different chemotherapy pathways in the treatment of cervical cancer through PI3K/AKT signaling pathway Methods 64 patients with cervical cancer were randomly divided into two groups according to the route of chemotherapy.Intravenous drip was used as the control group and arterial infusion as the experimental group.The expressions of PI3K,AKT,p-PI3K,p-AKT mRNA and protein were detected by qRT-PCR.and western blotting.The patients continued to receive chemotherapy for two courses,and the clinical efficacy and safety of the two groups were compared Results Compared with the paracancerous tissues,the expression levels of PI3K and AKT mRNA in the control group and the experimental group were significantly higher than those in the control group,hut the expression level of mRNA in the experimental group was significantly lower than that in the control group.Compared with the paracancerous tissues,the expression levels of PI3K.AKT,p-PI3K and p-AKT in the canj er tissues of the control group and the cxprnniental group were significantly higher than those of the control group(P<0.05).but the protein expression level of the experimental group was significantly lower than that of the control group(P<0.05).The effective remission rate of cervical cancer patients in the experimental group was significantly better than that in the control group(P<0.05),and the paracancerous invasion and lymph node metastasis in the experimental group were significantly lower than those in the control group(P<0.05)Conclusions The safety of cervical cancer patients in the experimental group is significantly higher than that in the control group(P<0.05).

关 键 词：紫杉醇脂质体 顺铂 PI3K/AKT信号通路 化疗 安全性 

分 类 号：R73[医药卫生—肿瘤]