胃溃疡患者再次感染幽门螺杆菌的影响因素  

Influence Factors of Re-infection of Helicobacter Pylori in Patients with Gastric Ulcer

作　　者：肖丹[1] 徐惠敏[1] 余中贵[1] XIAO Dan;XU Huimin;YU Zhonggui(Huizhou First Hospital,Huizhou 516001,China;不详)

机构地区：[1]惠州市第一人民医院,广东惠州516001

出　　处：《中外医学研究》2020年第16期19-22,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：惠州市科技计划项目(2018Y113)。

摘　　要：目的:探究胃溃疡患者再次感染幽门螺杆菌的影响因素。方法:选择2014年1月-2018年1月笔者所在医院收治的289例胃溃疡患者作为研究对象,失访11例,根据治疗后1年随访结果,将患者分成再次感染组(n=53)和正常组(n=225)。单因素分析胃溃疡患者一般资料,对差异有统计学意义的单因素进行非条件Logistic多因素回归分析,探究再次感染幽门螺杆菌的影响因素并建立预测模型。结果:278例患者Hp再次感染率为15.09%(53/278)。再次感染组中男性、年龄>40岁、体质指数>24.0 kg/m^2、有家族胃病史、服用非甾体类抗炎药、有吸烟史及饮酒史、糖尿病、饮食规律、喜食碳酸饮料及存在不良情绪比例均高于正常组(P<0.05);Logistic回归分析表明,服用非甾体类抗炎药[OR=2.140,95%CI(1.415,3.237)]、饮食不规律[OR=2.670,95%CI(1.451,4.911)]、不良情绪[OR=1.842,95%CI(1.277,2.658)]、性别[OR=1.416,95%CI(1.160,1.730)]和年龄[OR=1.107,95%CI(1.036,1.184)]均是胃溃疡患者再次感染幽门螺杆菌的独立影响因素(P<0.05)。结论:针对胃溃疡患者,临床宜根据性别、年龄、饮食、服药及心理状态等方面进行综合干预,以降低再次感染率,改善生活质量。Objective:To explore the influence factors of re-infection of helicobacter pylori in patients with gastric ulcer.Method:A total of 289 cases with gastric ulcer admitted to our hospital from January 2014 to January 2018 were selected as subjects,11 cases were lost to follow-up.According to the results of one year follow-up after treatment,patients were divided into the re-infection group (n=53) and the normal group (n=225).The basic information of two groups was analyzed by univariate analysis,and unconditional Logistic multivariate regression analysis was performed on the univariate factors with statistically significant differences,so as to explore the influence factors of re-infection of helicobacter pylori and establish a prediction model.Result:The re-infection rate in 278 patients was 15.09% (53/278).In the re-infection group,the proportion of male,age>40 years old,body mass index>24.0 kg/m^2,family history of gastropathy,use of non-steroidal anti-inflammatory drugs,history of smoking and drinking,diabetes,dietary rules,appetite for carbonated drinks and presence of adverse emotions were all higher than those of the normal group (P<0.05).Logistic regression analysis showed that taking non-steroidal anti-inflammatory drugs [OR=2.140,95%CI (1.415,3.237)],eating disorders [OR=2.670,95%CI (1.451,4.911)],negative emotion [OR=1.842,95%CI (1.277,2.658)],gender [OR=1.416,95%CI (1.160,1.730)] and age [OR=1.107,95%CI (1.036,1.184)] were independent influence factors of re-infection of helicobacter pylori in patients with gastric ulcer (P<0.05).Conclusion:For patients with stomach ulcer,comprehensive interventions should be carried out according to sex,age,diet,medication and psychological state,so as to reduce the re-infection rate and improve the quality of life.

关 键 词：胃溃疡 再次感染 幽门螺杆菌 影响因素 

分 类 号：R573.1[医药卫生—消化系统]