异甘草酸镁与谷氨酰胺联合肠内营养支持治疗重症急性胰腺炎的效果  

Effect of Magnesium Isosglycyrrhizinate and Glutamine Combined with Enteral Nutrition Support in the Treatment of Severe Acute Pancreatitis

作　　者：夏秀梅[1] 周伟[1] XIA Xiumei;ZHOU Wei(Xiaogan Central Hospital,Xiaogan 432000,China;不详)

机构地区：[1]孝感市中心医院,湖北孝感432000

出　　处：《中外医学研究》2020年第16期46-48,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究异甘草酸镁与谷氨酰胺联合肠内营养支持治疗重症急性胰腺炎的效果。方法:选取笔者所在医院2018年5月-2019年8月SAP患者82例,根据治疗方案不同分为两组,各41例。对照组给予肠内营养支持,观察组于对照组基础上加用异甘草酸镁、谷氨酰胺。对比两组疗效、治疗7、14 d的APACHEⅡ评分及治疗前后肠黏膜屏障功能指标[二胺氧化酶(DAO)、D-乳酸]水平。结果:观察组总有效率高于对照组(P<0.05);治疗7、14 d,观察组APACHEⅡ评分低于对照组(P<0.05);治疗后观察组血清DAO、D-乳酸水平低于对照组(P<0.05)。结论:异甘草酸镁与谷氨酰胺联合肠内营养支持治疗SAP患者,可降低APACHEⅡ评分,改善肠黏膜屏障功能,疗效显著。Objective:To investigate the effect of Magnesium Isosglycyrrhizinate and Glutamine combined with enteral nutritional support in the treatment of severe acute pancreatitis.Method:A total of 82 cases of SAP patients in our hospital from May 2018 to August 2019 were selected,according to different treatment schemes,they were divided into two groups.41 cases in each group.The control group was given enteral nutrition support,and the observation group was added with Magnesium Isosglycyrrhizinate and Glutamine on the basis of the control group.Compared the two groups of curative effect,APACHE Ⅱ score of treatment for 7,14 days and intestinal mucosal barrier function indexes before and after the treatment [diamine oxidase (DAO),D-lactate] levels.Result:The total effective rate of the observation group was higher than that of the control group (P<0.05).Treatment for 7,14 days,the APACHE Ⅱ score of study group were lower than those of the control group (P<0.05).After treatment,serum DAO and D-lactic acid levels in the observation group were lower than those in the control group (P<0.05).Conclusion:Magnesium Isosglycyrrhizinate,Glutamine combined with enteral nutrition support can reduce APACHE Ⅱ score and improve intestinal mucosal barrier function in SAP patients,with significant therapeutic effect.

关 键 词：异甘草酸镁 谷氨酰胺 肠内营养支持 重症急性胰腺炎 

分 类 号：R576[医药卫生—消化系统]