上皮特异性黏附分子在肿瘤中的表达研究进展  

Progression of the Research of Epithelial Cell Adhesion Molecule Express in Cancer

作　　者：许华丽 朱柯 冯燕 XU Huali;ZHU Ke;FENG Yan(Mianyang Hospital of Traditional Chinese Medicine,Mianyang 621000,China;不详)

机构地区：[1]绵阳市中医医院,四川绵阳621000 [2]西南医科大学附属口腔医院

出　　处：《中外医学研究》2020年第16期169-171,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：2015年泸州市人民政府-四川医科大学科技战略合作项目(2015LZCYD-S05(3/2))。

摘　　要：上皮特异性黏附分子(epithelial cell adhesion molecule,Ep-CAM)一种分子量为37KDa的Ⅰ型跨膜糖蛋白,介导上皮特异性细胞间黏附,局限性表达于正常组织上皮基底膜处,相关于细胞信号传递、迁移、增殖和分化等。不少研究者在肿瘤发生机制研究中发现Ep-CAM大量表达于快速增长的上皮性或上皮源性肿瘤组织中,参与Wnt信号转导通路,与肿瘤的发生、发展、侵袭、转移及预后有着密切联系,目前已成为肿瘤早期诊断和免疫靶向治疗的候选分子。本文就Ep-CAM的生物学特性及近年来其在相关肿瘤的研究进展做一综述,期望对肿瘤的早期诊断、治疗和预后有所帮助。Epithelial adhesion molecule (Ep-CAM) is a type I transmembrane glycoprotein with a molecular weight of 37KDa mediates the adhesion of epithelial-specific intercellular.Ep-CAM localized express at the epithelial basement membrane of normal tissues which is associated with the signaling,migration,proliferation and differentiation of cells.Lots of researchers have found that Ep-CAM is abundantly expressed in rapidly growing epithelial or epithelial-derived tumor tissues and is involved in Wnt signal transduction pathway,which is closely related to tumorigenesis,development,invasion,metastasis and prognosis.Ep-CAM has become a candidate molecule for the early diagnosis and immuno-targeted therapy of tumor.This article mainly reviews the biological characteristics of Ep-CAM and the recent research progress of it related to tumors,and hoping to be helpful for the early diagnosis,treatment and prognosis of tumors.

关 键 词：肿瘤 EP-CAM 肿瘤干细胞 肿瘤标记物 

分 类 号：R730.2[医药卫生—肿瘤]