黑色素瘤DNA甲基化基因研究进展  

The research progress of DNA methylation in melanoma

作　　者：郑舒丹 黄元华 程诗萌 亓发芝 金亮 刘天一 李世荣[6] 朱宁文 Zheng Shudan;Huang Yuanhua;Cheng Shimeng;Qi Fazhi;Jin Liang;Liu Tianyi;Li Shirong;Zhu Ningwen(Department of Dermatology,Huashan Hospital,Fudan University,Shanghai 200040,China;Hainan Medical College Graduate Shcool,Haikou 570100,China;Department of Plastic Surgery,Zhongshan Hospital,Fudan University,Shanghai 200040,China;China Pharmaceutical University Graduate School,Nanjing 210009,China;Department of Plastic Surgery,Huadong Hospital,Fudan University,Shanghai 200040,China;Department of Plastic Surgery,Southwest Hospital,Third Military Medical University,Chongqing 400038,China)

机构地区：[1]复旦大学附属华山医院皮肤科,上海200040 [2]海南医学院研究生院,海口570100 [3]复旦大学附属中山医院整形外科,上海200040 [4]中国药科大学研究生院,南京210009 [5]复旦大学附属华东医院整形外科,上海200040 [6]第三军医大学西南医院整形外科,重庆400038

出　　处：《中华整形外科杂志》2020年第6期701-706,共6页Chinese Journal of Plastic Surgery

基　　金：国家863计划(2014AA020705);上海市科委科技创新行动计划(19441909900)。

摘　　要：黑色素瘤(简称黑素瘤)是一种来源于黑素细胞的高度侵袭性和致命性的皮肤恶性肿瘤,具有转移早、死亡率高的特点。近几年,随着人们对黑素瘤发病机制的深入研究,发现表观遗传修饰特别是DNA甲基化方面被认为是黑素瘤发展和演变的普遍内在特征。该文对黑素瘤中异常DNA甲基化基因研究进展进行详细地回顾,并对DNA甲基化基因的生物标记作用进行总结,提示黑素瘤患者异常DNA甲基化基因的检测,有望作为黑素瘤患者的早期筛查指标和诊断标志。Melanoma is a highly invasive and lethal skin malignant tumor derived from melanocytes.It has the characteristics of high early metastasis and high mortality.In recent years,with the in-depth study of the pathogenesis of melanoma,it has been found that epigenetic modification,especially DNA methylation,is considered to be a universal intrinsic feature of melanoma development and evolution.This article reviews the research progress of abnormal DNA methylation genes in melanoma in detail,and summarizes the biomarker effect of DNA methylation genes,suggesting that the detection of abnormal DNA methylation genes in melanoma patients is hopeful as an early screening index and diagnostic marker for melanoma patients.

关 键 词：黑色素瘤 DNA甲基化 基因 生物标志物 

分 类 号：R739.5[医药卫生—肿瘤]