青光眼与生物节律  

Glaucoma and biological rhythm

作　　者：张敬学 王宁利 Zhang Jingxue;Wang Ningli(Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology&Visual Sciences,Beijing 100005,China)

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所眼科学与视觉科学北京市重点实验室,100005

出　　处：《国际眼科纵览》2020年第3期145-149,共5页International Review of Ophthalmology

基　　金：国家自然科学基金重点项目(81730027);北京市医院管理中心“青苗”计划(QML20180208)。

摘　　要：内在光感受性视网膜神经节细胞(intrinsically photosensitive retinal ganglion cells,ipRGC)是非形觉功能的主要光感受器,负责调节睡眠觉醒以及激素分泌等生物节律活动.青光眼作为一类特征性损害视网膜神经节细胞的疾病,同样可导致ipRGC及其相关传导通路的损伤,影响光信号的接受及光导引作用.青光眼患者中由ipRGC调节的非形觉功能出现损害的比例显著增高,包括睡眠障碍、激素分泌异常以及瞳孔对光反射功能下降等.研究青光眼与生物节律的关系有助于丰富青光眼临床诊疗内涵.The intrinsically photosensitive retinal ganglion cells(ipRGCs)are the main photoreceptors of the non-image-forming visual functions,and are responsible for regulating biological rhythm activities,such as sleep awakening and hormone secretion.Glaucoma,as a type of disease that characteristically damages retinal ganglion cells,can also lead to the damage of the ipRGCs and related visual pathways,and affect the reception and entrainment of light signals.The proportion of patients with damaged non-image-forming visual functions which regulated by ipRGCs is significantly increased in glaucoma patients,including sleep disorders,abnormal hormone secretion and decreased pupillary light reflection function,etc.These findings of glaucoma and biological rhythm further enrich the understanding of clinical diagnosis and treatment of such diseases.

关 键 词：生物节律 青光眼 内在光感受性视网膜神经节细胞 非形觉功能 

分 类 号：R775[医药卫生—眼科]