Ferriporphyrin-inspired MOFs as an artificial metalloenzyme for highly sensitive detection of H2O2 and glucose  

作　　者：Jiajia Chen Huajian Gao Zhihao Li Yingxue Li Quan Yuan 

机构地区：[1]Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education),College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China

出　　处：《Chinese Chemical Letters》2020年第6期1398-1401,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21925401,21675120,21904100);Changsha Municipal Science and Technology Projects,China(No.kq1901030)。

摘　　要：Metalloenzymes which employ metal species and organic ligands as central active sites play significant roles in various biological activities.Development of artificial metalloenzymes can help to understand the related physiological mechanism and promote the applications of metalloenzymes in biosynthesis,energy conversion and biosensing.In this work,inspired by the active sites of ferriporphyrin-based metalloenzymes,Fe-MOFs by using ferric as the metal center and a porphyrin analog as the organic liga nd were developed as an artificial metalloenzyme.The Fe-MOFs exhibit high peroxidase-like catalytic activity with excellent long-term stability.Moreover,highly sensitive biosensors were built to detect H2 O2 and glucose based on the Fe-MOFs.Such MOFs-based artificial metalloenzyme offers an efficient strategy for the development of highly stable and efficient metalloenzymes,showing great potential in catalysis,energy transfer,biosensing and medical diagnosis.

关 键 词：METALLOENZYME Metal-organic frameworks PEROXIDASE CATALYZE Stability 

分 类 号：O641.4[理学—物理化学] Q814[理学—化学]