胃蛋白酶原检测联合放大染色内镜检查在胃癌早期筛查中的应用研究  

Study on application of pepsinogen detection combined with magnifying staining endoscopic examination in early screening of gastric cancer

作　　者：宋玲莉 吴志轩[2] 谷和林 SONG Lingli;WU Zhixuan;GU Helin(Department of Gastroenterology,Xiushan County People′s Hospital,Xiushan,Chongqing 409900,China;Department of Gastroenterology,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400000,China)

机构地区：[1]重庆市秀山县人民医院消化内科,重庆秀山409900 [2]重庆医科大学附属第二医院消化内科,重庆400000

出　　处：《现代医药卫生》2020年第15期2357-2359,2362,共4页Journal of Modern Medicine & Health

摘　　要：目的探讨胃蛋白酶原检测联合放大染色内镜检查在胃癌早期筛查中的应用效果。方法选取2017年8月至2018年8月重庆市秀山县人民医院收治的行胃癌早期筛查患者180例,按是否存在胃癌分为研究组(74例)和对照组(106例),对照组为检查结果正常无胃癌者,研究组为早期胃癌患者,均行胃蛋白酶原、放大染色内镜检查,对比2组患者检查及诊断情况。结果研究组患者胃蛋白酶原Ⅰ、胃蛋白酶原Ⅰ/Ⅱ水平均较对照组低,胃蛋白酶原Ⅱ水平较对照组高,且进展期胃癌患者胃蛋白酶原Ⅰ、胃蛋白酶原Ⅰ/Ⅱ水平均较其他胃黏膜病变者高,胃蛋白酶原Ⅱ水平较其他胃黏膜病变者低,差异均有统计学意义(P<0.05);胃蛋白酶原联合放大染色内镜对胃癌早期筛查的准确率为97.30%,特异性为75.00%,灵敏度为98.59%,均明显高于单独应用胃蛋白酶原、放大染色内镜检查,差异均有统计学意义(P<0.05)。结论胃蛋白酶原联合放大染色内镜用于胃癌患者早期筛查中效能优越,值得选用。Objective To investigate the application effect of pepsinogen detection combined with magnifying staining endoscopic examination in early screening of gastric cancer.Methods A total of 180 patients with early screening for gastric cancer in Xiushan County People′s Hospital from August 2017 to August 2018 were selected and divided into the study group(n=74)and control group(n=106)according to whether existing gastric cancer.The control group was the normal subject without gastric cancer,and the study group was the patient with early gastric cancer.All subjects conducted the magnifying staining endoscopic examination and pepsinogen detection.The detection and diagnosis situation were compared between these two groups.Results The levels of pepsinogenⅠand pepsinogenⅠ/pepsinogenⅡin the study group were lower than those in the control group,and the level of pepsinogenⅡwas higher than that in the control group,moreover the levels of pepsinogenⅠand pepsinogenⅠ/pepsinogenⅡin the advanced gastric cancer patients were higher than those in the patients with other gastric mucosal lesions,while the level of pepsinogenⅡin the advanced gastric cancer patients were lower than those in the patients with other gastric mucosal lesions,and the differences were statistically significant(P<0.05).The accuracy rate of pepsinogen combined magnifying staining endoscopy for screening early gastric cancer was 97.30%,the specificity was 75.00%,and the sensitivity was 98.59%,which were higher than those of single use of pepsinogen and magnifying staining endoscopy,and the difference was statistically significant(P<0.05).Conclusion Pepsinogen combined with magnifying staining endoscopy has superior performance in early screening the patients with gastric cancer,and it is worth application.

关 键 词：胃蛋白酶原类 胃肿瘤 早期诊断 放大染色内镜 

分 类 号：R735.2[医药卫生—肿瘤] R730.43[医药卫生—临床医学]