左乙拉西坦单药治疗儿童癫痫的血清学变化  

Serological changes in children with epilepsy treated with Levetiracetam monotherapy

作　　者：唐煜 刘大鹏 杨志晓 田培超[4] TANG Yu;LIU Da-peng;YANG Zhi-xiao;TIAN Pei-chao(Department of Pediatrics,Henan Electric Power Hospital,Zhengzhou 450006,China;不详)

机构地区：[1]河南电力医院儿科,郑州450006 [2]河南省儿童医院神经内科 [3]河南省儿童医院NICU [4]郑州大学第一附属医院儿科

出　　处：《医药论坛杂志》2020年第7期46-48,52,共4页Journal of Medical Forum

基　　金：河南省医学科技攻关计划项目(201503064)。

摘　　要：目的观察应用左乙拉西坦(levetiracetam,LEV)单药治疗癫痫(epilepsy,EP)患儿,其治疗前后血清胰岛素样生长因子-1(IGF-1)和一氧化氮(NO)含量的变化。方法回顾性纳入2014年6月至2018年6月期间在本院就诊的癫痫患儿102例:其中试验组患儿52例(规律口服左乙拉西坦单药治疗),对照组50例(口服卡马西平片治疗)。试验组患儿年龄4~15岁(平均6.8岁),对照组患儿年龄5~17岁(平均7.1岁)。两组患儿分别在治疗前及治疗后12周收集患者血液,采用放射免疫分析法和硝酸酶还原法测定血清中IGF-1和NO水平。结果试验组患儿癫痫控制的总有效率为92.3%,显著高于对照组(P<0.05)。试验组患儿治疗12周后IGF-1和NO含量较治疗前均有明显变化:IGF-1水平明显升高(P<0.05),NO含量明显降低(P<0.05),差异具有统计学意义。对照组患儿12周随访时血清中IGF-1和NO水平与治疗前相比无明显变化(P>0.05)。治疗后,试验组患儿中IGF-1含量明显高于对照组患儿(P<0.05),试验组患儿中NO含量明显低于对照组患儿(P<0.05)。所有患儿用药期间未发生严重不良反应。结论左乙拉西坦单药通过调节血清IGF-1和NO水平,可有效保护患儿脑细胞并改善癫痫病情。Objective To observe the changes of serum insulin-like growth factor-1(IGF-1)and nitric oxide(NO)levels in children with epilepsy(EP)treated with levetiracetam(LEV).Methods The 102 consecutive children with epilepsy were retrospectively included in our study from June 2014 to June 2018.The treatment group included 52 patients(levetiracetam monotherapy),aged 4 to 15 years old(average 6.8 years old);The control group included 50 patients(Carbamazepine),aged 5 to 17 years old(average 7.1 years old).Blood samples were collected before and 12 weeks after treatment.Serum levels of IGF-1 and NO were measured by radioimmunoassay and nitrase reduction methods.Results After 12 weeks of treatment,the levels of IGF-1 and NO in the treatment group were significantly different from those before treatment:IGF-1 was significantly increased(P<0.05),and NO was significantly decreased(P<0.05).Serum IGF-1 and NO levels had no significant difference in the control group at 12 weeks follow-up(P<0.05).No serious adverse reactions occurred during the follow-up period.Conclusion Levetiracetam alone in the treatment of children with epilepsy,can protect brain cells and improve the condition of children by regulating serum levels of IGF-1 and NO.

关 键 词：儿童 癫痫 左乙拉西坦 胰岛素样生长因子-1 一氧化氮 

分 类 号：R971+.6[医药卫生—药品]