宫颈柱状上皮异位程度与高危型HPV清除率的相关性  

Correlation between the Degree of Ectopic Cervical Epithelium and the Clearance Rate of High-risk HPV

作　　者：马丽莎[1] 张雯[1] 谭露[1] 杨廷仙[1] 张粉 邓继红[1] MA Li-sha;ZHANG Wen;TAN Lu;YANG Ting-xian;ZHANG Fen;DENG Ji-gong(Department of Gynecology,Kunming Maternal and Child Health Hospital,Kunming Yunnan 654100,China)

机构地区：[1]昆明市妇幼保健院妇科,云南昆明654100

出　　处：《昆明医科大学学报》2020年第8期77-80,共4页Journal of Kunming Medical University

基　　金：云南省应用基础研究基金资助项目(2017FD241)。

摘　　要：目的对比宫颈柱状上皮异位程度与高危型HPV清除率,探求HPV持续感染是否应积极干预柱状上皮异位程度。方法选择仅高危型HPV阳性者作为研究对象。按柱状上皮异位程度分组,1 a后将各组与光滑宫颈HPV清除情况进行对比。结果育龄期组:Ⅱ和Ⅲ度柱状上皮异位与光滑组的转阴率,差异有统计学意义(P<0.05)。围绝经期组:各柱状上皮异位组分别与光滑组对比,差异有统计学意义(P<0.05)。结论育龄期HPV清除率与Ⅱ/Ⅲ度柱状上皮异位有相关性,提示HPV持续感染伴Ⅱ/Ⅲ度柱状上皮异位可积极干预。围绝经期HPV清除率与柱状上皮异位程度无关,反倒光滑宫颈清除率低,提示HPV持续感染伴光滑宫颈不容轻视,物理干预需谨慎。Objective To investigate whether patients with persistent HPV infection would actively interfere with the degree of ectopic HPV of columnar epithelium by comparing the degree of ectopic cervical columnar epithelium with the clearance rate of high risk type. Methods High-risk HPV positive patients were selected as subjects.According to the degree of heterotopic columnar epithelium, each group was compared with smooth cervical HPV clearance after 1 year. Results Childbearing age group: the negative rates of II and III degree columnar epithelial ectopic and smooth group were statistically significant(P < 0.05). Perimenopausal period group: compared with smooth group,,the difference in each columnar epithelial ectopic group was significant(P < 0.05). Conclusions HPV clearance rate during childbearing age was correlated with II/III degree columnar epithelial ectopic,suggesting that HPV persistent infection with II/III degree columnar epithelial ectopic could be actively intervened.Perimenopausal HPV clearance rate is not related to columnar epithelium ectopic, but smooth cervix clearance rate is low, suggesting that HPV persistent infection with smooth cervix should be given more attention, and physical intervention should be given with great care.

关 键 词：宫颈柱状上皮异位 光滑宫颈 高危型HPV感染 HPV清除率 

分 类 号：R737.33[医药卫生—肿瘤]