准直器角度优化对胃癌调强放疗计划影响的研究  

The Study of the Influence of the Angle of the Collimator on the Intensity-modulated Radiotherapy for Gastric Cancer

作　　者：申晖 SHEN Hui(Radiotherapy Department,People's Hospital of Yangjiang City,Yangjiang Guangdong 529500,China)

机构地区：[1]广东省阳江市人民医院放疗科,广东阳江529500

出　　处：《中国继续医学教育》2020年第21期112-114,共3页China Continuing Medical Education

基　　金：:2018年度阳江市医疗卫生类科技计划项目(名称:阿帕替尼联合化疗在复发性卵巢癌中的临床研究,编号:社发【2018】20);2019年度阳江市医疗卫生类科技计划项目(名称:关于共享经济中资金与信息安全的分析与探讨,编号:阳科通[50]号)。

摘　　要：目的探讨3种准直器角度优化对胃癌调强放疗计划影响。方法将2017年1月—2017年6月某院收治的9例胃癌患者作为研究对象,并在Monaco计划系统中使用除了准直器角度不同、其他各种参数都一致的3种不同的准直器角度优化技术设计3个调强放疗计划。主要剂量学参数包括PTV适形指数(CI)、均匀指数(HI)、平均剂量(Dmean)、治疗跳数(MU)、优化时间等,观察3种准直器角度上述指标值情况。结果 45°与90°的Dmean同0°相比差异有统计学意义(P <0.05),0°的MU明显大于90°与45°,优化时间明显短于45°、90°(P <0.05);但45°与90°的CI、HI、Dmean同0°相比差异无统计学意义(P> 0.05)。结论与常规的Co110直器角度优化相相比,Co1190与Co1145能够获得相当剂量的分布,并且能够减少MU,从而能够有效的提升临床治疗效果。Objective To investigate the effects of the optimization of three collimator angles on the intensity-modulated radiotherapy plan of gastric cancer. Methods From January 2017 to June 2017,9 patients with gastric cancer admitted in a hospital were used as the research objects, and three different criteria were used in the Monaco planning system except for different collimator angles and other parameters. Straightener angle optimization technology was used to design 3 IMRT plans. The main dosimetric parameters include PTV conformal index(CI), uniformity index(HI), average dose(Dmean), treatment jump(MU), optimization time, etc. Observe the above index values of the three collimator angles. Results Dmean at 45° and 90° was significantly different from 0°(P <0.05), MU at 0° was significantly larger than 90° and 45°, and optimization time was significantly shorter than 45° and 90°, which was significant(P <0.05);There was no difference in CI, HI, and Dmean compared with 0°(P > 0.05). Conclusion Compared with the conventional Coll0 straightener angle optimization, Coll90 and Coll45 can obtain equivalent dose distributions and reduce MU, which can effectively improve the clinical treatment effect.

关 键 词：准直器角度优化 胃癌 调强放疗计划 PTV适形指数 治疗跳数 均匀指数 

分 类 号：R730[医药卫生—肿瘤]