Hepsin、MMP-7、CD147与三阴性乳腺癌微血管密度的相关性分析  

Correlation between Hepsin,MMP-7,CD147 and microvessel density in triple-negative breast cancer

作　　者：聂琰 谭博[2] NIE Yan;TAN Bo(Department of Hematology and Endocrinology,the 82nd Army Hospital of Chinese People′s Liberation Army,Baoding,Hebei 071000,China;Department of Endocrinology,the First Hospital of Baoding,Baoding,Hebei 071000,China)

机构地区：[1]中国人民解放军陆军第八十二集团军医院血液内分泌科肿瘤血液病区,河北保定071000 [2]河北省保定市第一医院内分泌科,河北保定071000

出　　处：《国际检验医学杂志》2020年第15期1863-1867,共5页International Journal of Laboratory Medicine

摘　　要：目的探讨Hepsin、基质金属蛋白酶-7(MMP-7)、CD147与三阴性乳腺癌(TNBC)微血管密度(MVD)的相关性。方法选取2015年5月至2018年1月中国人民解放军陆军第八十二集团军医院收治的86例TNBC患者组织标本作为TNBC组,另选取同期中国人民解放军陆军第八十二集团军医院收治的80例非TNBC患者组织标本作为非TNBC组。比较两组Hepsin、MMP-7、CD147表达情况及MVD,并进行Pearson相关性分析。结果TNBC组Hepsin、MMP-7、CD147阳性表达率均明显高于非TNBC组,差异均有统计学意义(P<0.05)。Hepsin、MMP-7、CD147表达、MVD值与年龄、肿瘤直径、病理类型均无关(P>0.05);与月经情况、临床分期、组织学分级、淋巴结转移有关(P<0.05)。TNBC组织Hepsin、MMP-7、CD147同时阳性表达的MVD值均明显高于Hepsin、MMP-7及CD147单独阳性表达的MVD值,差异均有统计学意义(P<0.05)。经Pearson相关性分析显示,TNBC组织Hepsin、MMP-7、CD147阳性表达与MVD值均呈正相关(P<0.05)。结论Hepsin、MMP-7、CD147阳性表达与TNBC组织的MVD值均呈正相关,三者可能均与TNBC的高侵袭性有密切关系。Objective To investigate the correlation between Hepsin,matrix metalloproteinase-7(MMP-7),CD147 and microvessel density(MVD)in triple-negative breast cancer(TNBC).Methods From May 2015 to January 2018,the specimens of 86 TNBC patients in the 82nd Army Hospital of Chinese People′s Liberation Army were selected as TNBC group.The specimens of 80 non-TNBC patients in the same period were selected as non-TNBC group.The expression of Hepsin,MMP-7,CD147 and MVD were compared between the two groups and the Pearson correlation analysis was conducted.Results The positive expression rates of Hepsin,MMP-7,CD147 in TNBC group were significantly higher than those in non-TNBC group,and the differences were statistically significant(P<0.05).The expression of Hepsin,MMP-7,CD147 and MVD were not related to age,tumor diameter and pathological type(P>0.05),but related to menstruation,clinical stage,histological grade and lymph node metastasis(P<0.05).The MVD of positive expression of combination of Hepsin,MMP-7,CD147 in TNBC tissues were significantly higher than those of positive expression of single Hepsin,MMP-7,CD147,and the differences were statistically significant(P<0.05).By Pearson correlation analysis,the positive expression of Hepsin,MMP-7,CD147 in TNBC tissues was positively correlated with MVD(P<0.05).Conclusion The positive expression of Hepsin,MMP-7,CD147 is positively correlated with the MVD of TNBC tissues,which may be closely related to the high invasiveness of TNBC.

关 键 词：HEPSIN 基质金属蛋白酶-7 CD147 三阴性乳腺癌 微血管密度 

分 类 号：R737.9[医药卫生—肿瘤]