广东江门地区HPV病毒在女性感染者中的分布特征及其对宫颈癌筛查的价值研究  

Study on the distribution features of HPV virus among female infected women in Jiangmen region of Guangdong and its value for screening cervical cancer

作　　者：朱少萍 覃钰纯[1] 伍洁莹[1] ZHU Shao-ping(Jiangmen maternal and child care service centre,Jiangmen,Guangdong,529000,China)

机构地区：[1]江门市妇幼保健院,广东江门529000

出　　处：《齐齐哈尔医学院学报》2020年第10期1260-1262,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨广东江门地区HPV病毒在女性感染者中的分布特征及其对宫颈癌筛查的价值。方法选择2018年1月—2019年10月在本院门诊就诊及体检的妇女1864例作为研究对象。对调查对象进行HPV与TCT检测,并根据TCT结果将调查对象分为健康组1458例、慢性宫颈炎组183例、CINⅠ组109例、CINⅡ组50例、CINⅢ组44例及宫颈癌组20例,比较各组HPV感染情况并对江门地区HPV感染分布特征进行分析。结果本研究被纳入的1 864例患者中有382例患者被检测出HPV阳性,对去除其中重复检查病例外的291例进行分析研究。其中单一基因型阳性率为10.25%,多重感染阳性率为5.36%。低危型感染以HPV6、HPV11、HPV81为主,阳性率分别为0.80%、0.70%、1.88%,高危型感染以HPV16、HPV18、HPV52、HPV58为主,阳性率分别为2.20%、1.56%、1.72%与1.45%。26~35岁患者HPV阳性率最高为30.77%,46~55岁年龄段患者HPV阳性率最低为12.23%。HPV阳性率随宫颈病变严重程度的增加而明显上升(P<0.05)。结论广东江门地区HPV病毒感染率较高,高危型感染占比较大,26~35岁人群感染率最高,HPV感染阳性率随宫颈病变严重程度增加而显著升高,HPV检测有助于宫颈癌的早期诊断。Objective To explore the distribution characteristics of HPV virus among female infected women in Jiangmen region of Guangdong and its value for cervical cancer screening.Methods A total of 1864 women who were treated or received health examination in our outpatient clinic from January 2018 to October 2019 were selected as subjects of the study. The subjects were tested for HPV and TCT,and the subjects were divided into the healthy group( n = 1458),chronic cervicitis group( n = 183),CINⅠ group( n = 109),CINⅡ group( n= 50),CINⅢ group( n = 44),and cervical cancer group( n = 20) based on the TCT results. Compare the HPV infection status of each group and analyze the distribution characteristics of HPV infection in Jiangmen area.Results Of the 1864 patients included in this study,382 cases were HPV positive and 291 patients were finally included in the analysis afterexcluded the repeated examination.The positive rate of single genotype was 10.25%,and the positive rate of multiple infections was 5. 36%. Low-risk infections were mainly HPV6,HPV11,and HPV81,with positive rates of 0. 80%,0. 70%,and 1. 88%,respectively. High-risk infections were mainly HPV16,HPV18,HPV52,and HPV58,with positive rates of 2.20%,1.56%,1.72% and 1.45%. The highest HPV positive rate was in patients aged from 26 to 35 years old( 30.77%),and the lowest HPV positive rate was in patients aged from 46 to 55 years( 12.23%). The HPV positive rate increased significantly with the increase of severity of cervical lesions( P< 0.05). Conclusions The infection rate of HPV in Jiangmen area of Guangdong province is high,and the high-risk type infection accounts for a large proportion. The infection rate of 26 to 35-year-old people is the highest. The positive rate of HPV infection increases significantly with the increase of severity of cervical lesions. HPV detection is helpful for the early diagnosis of cervical cancer.

关 键 词：江门 HPV 女性感染者 分布特征 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]