ATF3在乳腺癌中的表达及临床意义  

Expression and clinical significance of ATF3 in breast cancer

作　　者：李树强[1] 赵文嫣[1] 滕虎成 Li Shuqiang;Zhao Wenyan;Teng Hucheng(Department of General Surgery,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院普通外科,沈阳110004

出　　处：《中国医师杂志》2020年第7期1030-1034,1039,共6页Journal of Chinese Physician

基　　金：中国医科大学青年骨干支持计划(指导计划类)(QGZD2018068)。

摘　　要：目的 分析活化转录因子3(ATF3)在乳腺癌中的表达情况及作用.方法 查询癌症和肿瘤基因表达图谱\基因表达汇编(TCGA\GEO)数据库信息,应用生物信息学方法分析ATF3在乳腺癌中的表达水平,绘制生存曲线,构建ATF3基因互作网络并行功能和通路富集分析.结果 乳腺癌中ATF3mRNA水平明显低于正常乳腺组织,经过化疗后其ATF3表达水平显著升高.生存分析发现经过系统治疗后,ATF3高表达组的乳腺癌患者,其生存期明显延长,差异有统计学意义(P<0.05).富集分析发现与乳腺癌相关的通路富集在Estrogen信号通路、丝裂原活化蛋白激酶(MAPK)信号通路、磷脂酰肌醇3-激酶-蛋白激酶B(PI3K-Akt)信号通路、Wnt信号通路、Breast cancer信号通路、cell cycle信号通路.结论 ATF3参与调控乳腺癌细胞的增殖,系统治疗后,ATF3的高表达预示着更好的预后.Objective To analyze the expression and role of activated transcription factor 3(ATF3)in breast cancer.Methods The Cancer Genome Atlas\Gene Expression Omnibus(TCGA\GEO)database information was queried,the expression level of ATF3 in breast cancer was analyzed by bioinformatics method and the survival curve was drawn.the parallel function and pathway enrichment analysis of ATF3 gene interaction network were constructed.Results The level of ATF3 mRNA in breast cancer was significantly lower than that in normal breast tissue,but the expression level of ATF3 was significantly increased after chemotherapy.Survival analysis found that after systematic treatment,the survival period of breast cancer patients in the ATF3 high expression group was significantly prolonged,and the difference was statistically significant(P<0.05).Enrichment analysis revealed that breast cancer-related pathways concentrate in Estrogens signaling pathway,mitogen-activated protein kinase kinases(MAPK)signaling pathway,phosphatidylinositol 3-kinase-protein kinase B(PI3K-Akt)signaling pathway,Wnt signaling pathway,Breast cancer signaling pathway,and Cell cycle signaling pathway.Conclusions ATF3 is involved in regulating the proliferation of breast cancer cells.After systematic treatment,the high expression of ATF3 indicates a better outcome.

关 键 词：转录激活因子3 乳腺肿瘤 生物信息学 

分 类 号：R737.9[医药卫生—肿瘤]