粒细胞集落刺激因子引发骨痛的机制及其治疗的研究进展  

Research progress in mechanism and treatment of granulocyte colony stimulating factor induced bone pain

作　　者：范志松[1] 邢栋[2] 董志杰[2] 郑学洪 高博[2] 冯莉[1] 左静[1] FAN Zhi-song;XING Dong;DONG Zhi-jie;ZHENG Xue-hong;GAO Bo;FENG Li;ZUO Jing(Department of Oncology,the Fourth Hospital of Hebei Medical University,Shijiazhuang HEBEI 050011,China;Department of Orthopedics,Hebei General Hospital,Shijiazhuang HEBEI 050051,China)

机构地区：[1]河北医科大学第四医院肿瘤内科,河北石家庄050011 [2]河北省人民医院骨科,河北石家庄050051

出　　处：《中国新药与临床杂志》2020年第7期390-393,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：中性粒细胞减少症是化疗药物常见的不良反应。粒细胞集落刺激因子(G-CSF)在临床中被用来预防和治疗放化疗引起的粒细胞减少症。骨痛是G-CSF最常见的不良反应。G-CSF可能通过骨髓定性和定量扩张、刺激外周神经、促进炎性因子产生、影响骨代谢等病理生理机制引发骨痛,研究显示萘普生和氯雷他定可以治疗G-CSF导致的骨痛。Neutropenia is a common adverse reaction of chemotherapy. Granulocyte colony stimulating factor(G-CSF)is used to prevent and treat neutropenia caused by radiotherapy and chemotherapy. Bone pain is the most common adverse reaction of G-CSF. G-CSF may cause bone pain through some pathophysiological mechanisms, such as qualitative and quantitative expansion of bone marrow, stimulation of peripheral nerves, promotion of inflammatory factors, and influence of bone metabolism. Studies have shown that naproxen and loratadine can treat bone pain caused by G-CSF.

关 键 词：粒细胞集落刺激因子 骨痛 药物不良反应 治疗结果 

分 类 号：R730.5[医药卫生—肿瘤]