溴结构域蛋白4在转录调节与肿瘤形成中的作用及其抑制剂的研究进展  

Research progress of bromodomain 4 in transcriptional regulation and neoplastic processes and its inhibitors

作　　者：杨林瑞 张风河[1] YANG Linrui;ZHANG Fenghe(Department of Oral and Maxillofacial Surgery,Stomatological Hospital,School of Stomatology,Shandong University/Shandong Provincial Key Laboratory of Oral Tissue Regeneration/Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration,Ji’nan 250012,China)

机构地区：[1]山东大学口腔医学院.口腔医院口腔颌面外科/山东省口腔组织再生重点实验室/山东省口腔生物材料与组织再生工程实验室,山东济南250012

出　　处：《中国普通外科杂志》2020年第7期890-897,共8页China Journal of General Surgery

基　　金：山东省自然科学基金资助项目(ZR201709270028)。

摘　　要：溴结构域蛋白4(BRD4)作为溴域及超末端结构家族中的一员,通过调节细胞基因转录调节细胞周期,在正常细胞以及肿瘤细胞的生理活动中扮演着重要角色。作为一种转录和表观遗传调控因子,BRD4基因的过度表达以及基因重排和基因突变常与多种疾病、尤其是恶性肿瘤的发生有关。笔者对BRD4及其抑制剂在转录调节中的功能及其与肿瘤细胞的相互作用进行综述与分析,从而为相应的临床治疗提供新的思路。Bromodomain 4(BRD4), a member of the bromodomain and extraterminal protein family, plays an important role in the physiological activities of normal cells and tumor cells by regulating gene transcription and cell cycle. As a transcriptional and epigenetic regulator, BRD4 gene overexpression, rearrangement and mutation are often associated with a variety of diseases, especially malignant tumors. Here, the authors review and analyze the function of BRD4 and its inhibitors in transcriptional regulation and their interaction with tumor cells, hoping to provide new ideas for relevant clinical treatment.

关 键 词：溴结构域蛋白4 转录因子 癌基因 抑制剂 综述文献 

分 类 号：R73[医药卫生—肿瘤]