人粒细胞巨噬细胞刺激因子含漱预防放射性口腔黏膜炎的疗效观察  

Observation on the curative effect of hGM-CSF gargles in the prevention of radiation-induced oropharyngeal mucositis

作　　者：刘尚贤[1] 张瑜[1] 郑茁[1] 张春[1] LIU Shangxian;ZHANG Yu;ZHENG Zhuo;ZHANG Chun(Fujian Provincial Cancer Hospital,Afiliated Cancer Hospital of Fujian Medical University,Fujian,Fuzhou 350014,China)

机构地区：[1]福建省肿瘤医院福建医科大学附属肿瘤医院,福建福州350014

出　　处：《中国医药科学》2020年第14期72-74,108,共4页China Medicine And Pharmacy

摘　　要：目的 分析人粒细胞巨噬细胞刺激因子含漱对放射性口腔黏膜炎的预防效果.方法 选取我院收治的88例接受放射治疗的头颈部恶性肿瘤患者为研究对象,按随机抽签法分为对照组和预防组,对照组采用生理盐水+碳酸氢钠含漱液清洗口腔,预防组在对照组基础上加以尤尼芬漱口液进行治疗,比较两组口腔黏膜炎分级情况、出现Ⅲ-Ⅳ度放射性口腔黏膜炎的时间以及口咽疼痛评分.结果 预防组口腔黏膜发生率为82.22%,远低于对照组的97.67%,且发生口腔黏膜炎的程度轻于对照组(P<0.05),出现Ⅲ-Ⅳ度放射性口腔黏膜炎的时间晚于对照组(P<0.05),患者口咽疼痛程度远轻于对照组(P<0.05).结论 人粒细胞巨噬细胞刺激因子含漱预防放射性口腔黏膜炎疗效确切,值得临床应用推广.Objective To analyze the preventive effect of human granulocyte macrophage colony-stimulating factor(hGM-CSF) gargle on radiation-induced oropharyngeal mucositis. Methods A total of 88 patients with head and neck malignant tumors treated by radiotherapy in our hospital were selected as research subjects. They were divided into the control group and the prevention group according to the random drawing method. The control group used normal saline + sodium bicarbonate gargle to clean the oral cavity, while the prevention group was treated with hGMCSF gargle on the basis of the control group, and the oral mucositis grading status, the time of occurrence of Ⅲ-Ⅳ degree radiation-induced oropharyngeal mucositis and the oropharyngeal pain score were compared between the two groups. Results The incidence of oral mucosa in the prevention group was 82.22%, which was much lower than 97.67% in the control group, and the severity was lighter than that in the control group(P < 0.05). The appearance time of Ⅲ-Ⅳ degree radiation-induced oropharyngeal mucositis in the prevention group was later than that in the control group(P < 0.05). The oropharyngeal pain in the prevention group was much lighter than that in the control group(P < 0.05). Conclusion hGM-CSF gargle has a definite curative effect in preventing radiationinduced oropharyngeal mucositis, and it is worthy of clinical application and promotion.

关 键 词：人粒细胞巨噬细胞 放射性口腔黏膜炎 头颈部肿瘤 口咽疼痛评分 

分 类 号：R739.63[医药卫生—肿瘤]