近日节律基因Per1对恶性肿瘤的侵袭、转移及凋亡影响的研究进展  

Recent Advances in Effects of Circadian Gene Per1 on Invasion,Metastasis and Apoptosis of Malignant Tumors

作　　者：池昌兴 李文辉[1] 侯宇[1] 李岚[1] 夏耀雄[1] 王丽[1] 常莉[1] CHI Changxing;LI Wenhui;HOU Yu;LI Lan;XIA Yaoxiong;WANG Li;CHANG Li(Radiotherapy Department,The Third Affiliated Hospital of Kunming Medical University,Kunming 650000,China)

机构地区：[1]昆明医科大学第三附属医院放疗科,昆明650000

出　　处：《肿瘤防治研究》2020年第7期553-557,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81860536,81560488,81660504);云南省高层次卫生技术人才培养专项(H-201624);云南省卫生科技计划项目(2017NS191,2018NS0064,2018NS0065)。

摘　　要：近日节律基因是细胞中的一组能够通过自身表达和调控形成自激震荡产生近日节律变化的基因。这些基因能够维持和调控生物的许多生理生化活动,使其按照一定的周期性规律、有序地运行,从而更好地适应周围环境。Period1(Per1)基因是一种重要的近日节律基因,在近日节律系统中处于核心地位。研究表明,Per1的异常表达和节律改变与多种恶性肿瘤的发生发展高度相关,但机制尚未完全明确。本文将就Per1对恶性肿瘤的侵袭、转移、凋亡的影响及相关机制作一综述。Circadian genes are a group of genes in cells that can modulate circadian rhythm by self-expression and regulation of self-excited oscillations.These genes can maintain and regulate many physiological and biochemical activities of the human body to operate according to a certain periodic rule and order,so as to be better adapt to the surrounding environment.Period1(Per1)gene is an important circadian rhythm gene and is at the core of circadian rhythm system.Studies have shown that the abnormal expression of Per1 and rhythm change are highly correlated with the occurrence and development of a variety of malignant tumors,but the mechanism is not fully clear.This article will review the effect of Per1 on the invasion,metastasis and apoptosis of malignant tumors and the related mechanism.

关 键 词：近日节律 Per1基因 恶性肿瘤 侵袭 转移 凋亡 

分 类 号：R730.231[医药卫生—肿瘤]