内蒙古地区环境因素与胰腺癌发病的关联性研究  

Study on the correlation between environmental factors and pancreatic cancer in Inner Mongolia

作　　者：林靖[1] 阿斯楞[2] 马月宏 肖瑞 赵建国[2] 张萌 赵海平[2] 闫环宇 王婷 张琪[5] 王福林 董紫微 LIN Jing;A Si-leng;MA Yue-hong(Department of Clinical Nutrition,Affiliated Hospital of Inner Mongolia Medical University,Hohhot Inner Mongolia 010050,China;Dean's Office,Inner Mongolia Medical University,Hohhot Inner Mongolia 010050,China;School of Basic Medicine,Inner Mongolia Medical University,Hohhot Inner Mongolia 010050,China)

机构地区：[1]内蒙古医科大学附属医院临床营养科,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院肝胆外科,内蒙古呼和浩特010050 [3]内蒙古医科大学教务处,内蒙古呼和浩特010050 [4]内蒙古医科大学基础医学院,内蒙古呼和浩特010050 [5]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010050

出　　处：《临床和实验医学杂志》2020年第13期1450-1455,共6页Journal of Clinical and Experimental Medicine

基　　金：内蒙古医科大学科技百万工程项目(编号:YKD2016KJBW006);内蒙古医科大学实验室开放基金(编号:2019ZN12)。

摘　　要：目的探讨内蒙古地区环境因素对胰腺癌易感性的影响。方法采用病例-对照研究的方法,选取2013年1月至2015年3月内蒙古医科大学附属医院确诊的254例胰腺癌患者作为病例组,选取同期健康体检的人群277例作为对照组。两组对象均面对面地进行问卷调查,调查内容包括一般情况、饮食习惯、生活方式、病史等。通过单因素及多因素非条件Logistic回归分析评价胰腺癌的环境影响因素。结果单因素非条件Logistic回归分析显示,过量食用肉类、吸烟、吸烟量、饮酒、饮酒量、2型糖尿病史、胰腺炎病史、胰腺癌家族史、癌症家族史是胰腺癌发生的危险因素;多因素分析显示,大量吸烟(OR=2.249,95%CI:1.085~4.660)、过量饮酒(OR=2.030,95%CI:1.013~4.488)、2型糖尿病史(OR=21.073,95%CI:2.436~182.323)与胰腺癌发生有关。结论大量吸烟、过量饮酒、2型糖尿病史是胰腺癌发病的环境危险因素,应当是胰腺癌预防的重点。Objective To explore the influence of environmental factors on pancreatic cancer susceptibility in Inner Mongolia.Methods254 patients with pancreatic cancer diagnosed in Affiliated Hospital of Inner Mongolia Medical University from January 2013 to March 2015 were selected as case group,and 277 people who received health examination at the same time were selected as control group,in this case-control study.The questionnaire was used to conduct face-to-face survey on the subjects.The survey included basic information,dietary habits,living habits,medical history.Through univariate and multivariate unconditional Logistic regression,the environmental factors of pancreatic cancer were analyzed.Results Univariate unconditional Logistic regression analysis showed that excessive consumption of meat,smoking,smoking amount,drinking,drinking amount,history of type 2 diabetes,history of pancreatitis,family history of pancreatic cancer and family history of cancer were risk factors for pancreatic cancer;Multivariate unconditional Logistic regression analysis showed that heavy smoking(OR=2.249,95%CI:1.085-4.660),excessive drinking(OR=2.030,95%CI:1.013-4.488),and a history of type 2 diabetes(OR=21.073,95%CI:2.436-182.323)were associated with pancreatic cancer.Conclusion Massive smoking,excessive drinking and type 2 diabetes history are the environmental risk factors of pancreatic cancer,which may be the focus of pancreatic cancer prevention.

关 键 词：胰腺癌 环境因素 关联性研究 

分 类 号：R735.9[医药卫生—肿瘤]