乳头糜烂性腺瘤病  

A case of erosive adenomatosis of nipple

作　　者：余音[1] 阎衡[1] 叶秀峰[2] 张颖[1] 冯林[1] 江阳[1] 高涛[1] 刘素桃[1] 李晶[1] YU Yin;YAN Heng;YE Xiu-feng;ZHANG Ying;FENG Lin;JIANG Yang;GAO Tao;LIU Su-tao;LI Jin(Department of Dermatology,Chongqing Hospital of Tnulitioiuil Chinese Medicine,Chongqing 400011,China)

机构地区：[1]重庆市中医院皮肤科,重庆400011 [2]重庆医科大学临床病理诊断中心,重庆400016

出　　处：《临床皮肤科杂志》2020年第7期420-422,共3页Journal of Clinical Dermatology

摘　　要：报告1例乳头糜烂性腺瘤病。患者女,31岁。右侧乳头红斑、糜烂,间断性血性溢液半年,不伴疼痛。皮损组织病理检查:肿瘤位于真皮内,与表皮相连,无包膜,可见乳腺导管上皮细胞明显增生,形成大小不等的管样结构和实体细胞巢,周围可见肌上皮细胞包绕。免疫组化:细胞角蛋白(CK)5/6阳性,抑癌基因(p63)、钙调蛋白(Caplonin)及平滑肌肌动蛋白(SMA)阳性,提示肌上皮细胞的完整性。诊断:乳头糜烂性腺瘤病。患者病灶完整切除后,随访18个月,未见复发。A case of erosive adenomatosis of nipple is reported. A 31-year-old female presented with intermittent and painless hemorrhagic discharge accompanied by erythema and erosion on the right nipple for six months. Histopathology revealed that the tumor was connected to the epidermis without envelope in the dermis, and the proliferated epithelial luminal cells formed lumens or cell nests of unequal sizes. The basal-myoepithelial cell layer was intact. Immunohistochemical analysis showed that cytokeratin5/6(CK5/6)was positive in the hyperplastic of glandular epithelium;the myoepithelial markers, such as tumor suppressor genes(p63), calponin and smooth muscle actin(SMA), were positive, indicating that the myoepithelial cell layer was intact. The diagnosis of erosive adenomatosis of nipple was made. The tumor was resected completely and no relapse occurred in the 18-month follow-up.

关 键 词：乳头 糜烂性腺瘤病 

分 类 号：R737.9[医药卫生—肿瘤]