Food groups, diet quality and colorectal cancer risk in the Basque Country  

作　　者：Iker Alegria-Lertxundi Carmelo Aguirre Luis Bujanda Francisco J Fernandez Francisco Polo JoseMªOrdovas MªCarmen Etxezarraga Inaki Zabalza Mikel Larzabal Isabel Portillo Marian M de Pancorbo Koldo Garcia-Etxebarria Ana MªRocandio Marta Arroyo-Izaga 

机构地区：[1]Department of Pharmacy and Food Sciences,Faculty of Pharmacy,University of the Basque Country UPV/EHU,Vitoria-Gasteiz 01006,Spain [2]Pharmacovig ilance Unit,Galdakao-Usansolo University Hospital,Osakidetza,Galdakao 48960,Spain [3]Department of Gastroenterology,Donostia University Hospital/Biodonostia,University of the Basque Country UPV/EHU,Centro de Investigación Biomédica en Red de Enfermedades Hepaticas y Digestivas(CIBERehd),San Sebastian 20014,Spain [4]Department of Gastroenterology,Galdakao-Usansolo University Hospital,Osakidetza,Galdakao 48960,Spain [5]Department of Gastroenterology,Basurto University Hospital,Osakidetza,Bilbao 48013,Spain [6]Nutrition and Genomics Laboratory,Jean Mayer Human Nutrition Research Center on Aging,Tufts University,Boston,Massachusetts 02111,United States of America,IMDEA Food,Madrid 28049,Spain [7]Department of Pathology,Basurto University Hospital,Osakidetza,Bilbao 48013,Spain [8]Department of Physician and Surgeon Specialities,University of the Basque Country UPV/EHU,Leioa 48940,Spain [9]Department of Pathology,Galdakao-Usansolo University Hospital,Osakidetza,Galdakao 48960,Spain [10]Department of Pathology,Donostia Hospital/Biodonostia,Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd),San Sebastian 20014,Spain [11]Colorectal cancer screening programme,Osakidetza,Bilbao 48011,Spain [12]BIOMICs Research Group,University of the Basque Country UPV/EHU,Vitoria-Gasteiz 01006,Spain [13]Biodonostia,Gastrointestinal genetics group,Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd),San Sebastian 20014,Spain

出　　处：《World Journal of Gastroenterology》2020年第28期4108-4125,共18页世界胃肠病学杂志（英文版）

基　　金：Supported by the Department of Health and Consumer Affairs,Basque Government,No.2011111153;Saiotek,Basque Government,No.S-PE12UN058;Pre-doctoral grant from the Basque Government,NO.PRE_2015_2_0084;and United States Department of Agriculture—Agricultural Research Service,No.58-1950-4-003.

摘　　要：BACKGROUND The results obtained to date concerning food groups,diet quality and colorectal cancer(CRC)risk vary according to criteria used and the study populations.AIM To study the relationships between food groups,diet quality and CRC risk,in an adult population of the Basque Country(North of Spain).METHODS This observational study included 308 patients diagnosed with CRC and 308 ageand sex-matched subjects as controls.During recruitment,dietary,anthropometric,lifestyle,socioeconomic,demographic and health status information was collected.Adherence to the dietary recommendations was evaluated utilizing the Healthy Eating Index for the Spanish Diet and the MedDietScore.Conditional logistic regressions were used to evaluate the associations of food group intakes,diet quality scores,categorized in tertiles,with CRC risk.RESULTS The adjusted models for potential confounding factors showed a direct association between milk and dairy products consumption,in particular high-fat cheeses[odds ratio(OR)third tertile vs first tertile=1.87,95%confidence intervals(CI):1.11-3.16],and CRC risk.While the consumption of fiber-containing foods,especially whole grains(OR third tertile vs first tertile=0.62,95%CI:0.39-0.98),and fatty fish(OR third tertile vs first tertile=0.53,95%CI:0.27-0.99)was associated with a lower risk for CRC.Moreover,higher MD adherence was associated with a reduced CRC risk in adjusted models(OR third tertile vs first tertile=0.40,95%CI:0.20-0.80).CONCLUSION Direct associations were found for high-fat cheese,whereas an inverse relation was reported for fiber-containing foods and fatty fish,as well as adherence to a Mediterranean dietary pattern.

关 键 词：Colorectal cancer Food group Dietary quality Mediterranean diet RISKFACTORS Case-control study 

分 类 号：R735.34[医药卫生—肿瘤]