联萘酚多氢键硫脲催化合成1,4-二氢吡啶衍生物  

Syntheses of 1,4-Dihydropyridine Derivatives Catalyzed by BINOL Multi-Hydrogen Bonded Thiourea

作　　者：秦婷 莫丽 陈平平 安雪婕 陈治明 Qin Ting;Mo Li;Chen Pingping;An Xuejie;Chen Zhiming(Key Laboratory of Functional Materials Chemistry of Guizhou Province,School of Chemistry and Materials Science,Guizhou Normal University,Guiyang,550001)

机构地区：[1]贵州师范大学化学与材料科学学院,贵州省功能材料化学重点实验室,贵阳550001

出　　处：《化学通报》2020年第7期665-671,共7页Chemistry

基　　金：国家自然科学基金项目(21362006)资助。

摘　　要：本文合成了三种具有多氢键的联萘酚轴手性硫脲催化剂,并将其用于催化合成1,4-二氢吡啶衍生物。结果显示,所合成的新型多氢键硫脲均表现出较好的催化作用,能有效地提高1,4-二氢吡啶衍生物的收率和对映选择性。所有新化合物结构均经过1H NMR、13C NMR、IR、熔点等表征所确认。Three kinds of structure-symmetric thiourea catalysts containing multi-hydrogen bond with binol axial chiral were synthesized and successfully applied to the syntheses of 1,4-dihydropyridine derivatives.The results showed that the synthesized polyhydrogen-bonded thioureas have better catalytic activity,which can effectively improve the yield and enantioselectivity of the 1,4-dihydropyridine derivatives.All new compounds were characterized by 1H NMR、13C NMR、IR、melting point and so on.

关 键 词：催化剂 1 4-二氢吡啶 硫脲 合成 

分 类 号：O626.32[理学—有机化学]