Nuclear Factor I/A Controls A-fiber Nociceptor Development  

作　　者：Lu Qi Guangjuan Yin Yongchao Zhang Yeqi Tao Xiaohua Wu Richard M.Gronostajski Mengsheng Qiu Yang Liu 

机构地区：[1]College of Life Sciences,Zhejiang University,Hangzhou 310058,China [2]Zhejiang Key Laboratory of Organ Development and Regeneration,Institute of Life Sciences,Hangzhou Normal University,Hangzhou 310036,China [3]Department of Biochemistry,Program in Genetics,Genomics and Bioinformatics,Center of Excellence in Bioinformatics and Life Sciences,State University of New York at Buffalo,Buffalo,NY 14203,USA

出　　处：《Neuroscience Bulletin》2020年第7期685-695,共11页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (31771621,31171071 and 31671093);the Research Foundation for Advanced Talents from Hangzhou Normal University and the New York State Stem Cell Science contracts C026429 and C030133。

摘　　要：Noxious mechanical information is transmitted through molecularly distinct nociceptors,with pinprickevoked sharp sensitivity via A-fiber nociceptors marked by developmental expression of the neuropeptide Y receptor 2(Npy2 r)and von Frey filament-evoked punctate pressure information via unmyelinated C fiber nociceptors marked by MrgprD.However,the molecular programs controlling their development are only beginning to be understood.Here we demonstrate that Npy2 r-expressing sensory neurons are in fact divided into two groups,based on transient or persistent Npy2 r expression.Npy2 r-transient neurons are myelinated,likely including A-fiber nociceptors,whereas Npy2 r-persistent ones belong to unmyelinated pruriceptors that co-express Nppb.We then showed that the transcription factors NFIA and Runx1 are necessary for the development of Npy2 r-transient A-fiber nociceptors and MrgprD^+C-fiber nociceptors,respectively.Behaviorally,mice with conditional knockout of Nfia,but not Runx1 showed a marked attenuation of pinprick-evoked nocifensive responses.Our studies therefore identify a transcription factor controlling the development of myelinated nociceptors.

关 键 词：Dorsal root ganglion Acute pain Pinprick pain Npy2r NPPB NOCICEPTOR A-fiber mechanonociceptor 

分 类 号：R741[医药卫生—神经病学与精神病学]