序贯放化疗对晚期子宫内膜癌患者术后辅助治疗疗效及血清HE4 CA125水平的影响  

Effects of Sequential Chemoradiotherapy on Curative Effect of Postoperative Adjuvant Therapy for Patients with Advanced Endometrial Cancer and Levels of Serum HE4 CA125

作　　者：郭玮[1] 刁海丹[1] GUO Wei;DIAO Haidan(Dalian Third People's Hospital,Liaoning Dalian 116033,China)

机构地区：[1]辽宁省大连市第三人民医院妇科,辽宁大连116033

出　　处：《河北医学》2020年第7期1104-1107,共4页Hebei Medicine

基　　金：辽宁省大连市医学科学研究计划项目,(编号:1911027)。

摘　　要：目的:探讨序贯放化疗对晚期子宫内膜癌患者术后辅助治疗疗效及血清HE4、CA125水平的影响.方法:回顾性分析2015年10月至2017年10月我院收治的80例晚期子宫内膜癌患者的临床资料,按照治疗方法不同分为对照组(n=40)和观察组(n=40),对照组给予常规辅助放化疗,观察组给予序贯放化疗,比较两组临床疗效、血清糖类抗原125(CA125)、人附睾蛋白(HE4)、并发症发生率、肿瘤转移率、生存率及生存期.结果:治疗后观察组总有效率高于对照组(P<0.05);治疗后观察组血清HE4、CA125水平低于对照组(P<0.05);观察组并发症发生率低于对照组(P<0.05);观察组肿瘤转移率低于对照组(P<0.05);对患者进行2年的随访,观察组2年生存率高于对照组,生存期优于对照组(P<0.05).结论:序贯放化疗对晚期子宫内膜癌患者术后辅助治疗疗效较好,可降低血清HE4、CA125水平,减少并发症发生率和肿瘤转移率,提高生存质量.Objective:To explore effects of sequential chemoradiotherapy on curative effect of postoperative adjuvant therapy for patients with advanced endometrial cancer(EC)and levels of serum HE4,CA125.Methods:The clinical data of 80 patients with advanced endometrial cancer from October 2015 to October 2017 were analyzed retrospectively,According to different treatment methods,they were divided into control group(n=40)and observation group(n=40).The control group was given routine adjuvant chemoradiotherapy,while observation group was given sequential chemoradiotherapy.The clinical curative effect,serum carbohydrate antigen 125(CA125),human epididymis protein(HE4),incidence of complications,tumor metastasis rate,survival rate and survival time were compared between the two groups.Results:After treatment,total response rate of observation group was higher than that of control group(P<0.05).After treatment,levels of serum HE4 and CA125 in observation group were lower than those in control group(P<0.05).The incidence of complications in observation group was lower than that in control group(P<0.05).The tumor metastasis rate in observation group was lower than that in control group(P<0.05).The patients were followed up for 2 year.The 2-year survival rate of observation group was higher than that of control group,and survival time was better than that of control group(P<0.05).Conclusion:The effects of sequential chemoradiotherapy are good on curative effect of postoperative adjuvant therapy for patients with advanced EC.It can reduce levels of serum HE4 and CA125 level,reduce incidence of complications and tumor metastasis rate,and improve quality of life.

关 键 词：子宫内膜癌 晚期 序贯放化疗 辅助治疗 

分 类 号：R737.33[医药卫生—肿瘤]