脑小血管病合并直立性低血压患者认知功能状态研究  

Cognitive Function of Cerebral Small Vessel Disease Combined with Orthostatic Hypotension Patients

作　　者：杨毅 张拥波[1] YANG Yi;ZHANG Yongbo(Department of Neurology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院神经内科,北京市100050

出　　处：《实用心脑肺血管病杂志》2020年第8期43-46,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金资助项目(81671191)。

摘　　要：背景脑小血管病(CSVD)常见于老年人,是血管性认知障碍的常见病因,而直立性低血压(OH)亦可增加心脑血管疾病发生风险。CSVD合并OH患者认知障碍是否加重需进一步探讨。目的分析CSVD合并OH患者认知功能状态。方法选取2017年1月—2019年9月首都医科大学附属北京友谊医院神经内科收治的CSVD患者84例,根据OH发生情况分为CSVD+OH组48例和CSVD组36例;另选取本院同期体检健康者34例作为对照组。分别比较三组简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)亚项评分及总分。结果三组时间定向力、空间定向力、瞬时记忆、命名、复述、阅读、理解、书写评分比较,差异无统计学意义(P>0.05)。CSVD+OH组、CSVD组注意力和计算力、延迟记忆、视空间评分及MMSE总分低于对照组(P<0.05)。三组语言、抽象、定向力评分比较,差异无统计学意义(P>0.05)。CSVD+OH组和CSVD组视空间与执行功能、命名、注意力、延迟回忆评分及MoCA总分低于对照组,CSVD+OH组视空间与执行功能、延迟回忆评分及MoCA总分低于CSVD组(P<0.05)。结论与单纯CSVD患者相比,CSVD合并OH患者认知障碍更明显,其中以视空间与执行功能、延迟回忆能力下降为主。Background Cerebral small vessel disease(CSVD)is common in the elderly,and is a common cause of vascular cognitive impairment,and orthostatic hypotension(OH)also can increase the risk of cardiocerebral vascular diseases.Whether cognitive dysfunction in patients with CSVD combined with OH is aggravated needs further discussion.Objective To explore the cognitive function of CSVD combined with OH patients.Methods 84 cases of patients with CSVD in Department of Neurology,Beijing Friendship Hospital,Capital Medical University from January 2017 to September 2019 were selected,and they were divided into CSVD+OH group(n=48)and CSVD group(n=36)according to incidence of OH;34 cases of health people were selected as control group.The subitem score and total score of MMSE,MoCA were compared in the three groups.Results There was no significant difference of emporal orientation force,spatial orientation force,instant memory,naming,retelling,reading,understanding or writing score in the three groups(P>0.05).Compared with control group,attention and calculation,delayed recall,visuospatial score and MMSE total score were lower in CSVD+OH group and CSVD group(P<0.05).There was no significant difference of language,abstract,orientation score in three groups(P>0.05).Compared with control group,visuospatial and executive,naming,attention,delayed recall score and MoCA total score of CSVD+OH group and CSVD group were lower(P<0.05);compared with CSVD group,visuospatial and executive,delayed recall score and MoCA total score of CSVD+OH group were lower(P<0.05).Conclusion Compared with the patients with CSVD alone,CSVD combined with OH patients have relatively obvious cognitive impairment,especially decreased in visuospatial and executive and delayed recall.

关 键 词：大脑小血管疾病 直立性低血压 认知障碍 相关性 

分 类 号：R743[医药卫生—神经病学与精神病学]