探讨血清胆固醇含量对抑郁障碍患者认知功能的影响  

Effects of serum cholesterol content on cognitive function in patients with depression disorder

作　　者：郑天生[1] 董周浒 张赢斌 林光耀 叶敏捷[1] ZHENG Tiansheng;DONG Zhouhu;ZHANG Yingbin;LIN Guangyao;YE Minjie(Depression Diagnosis and Treatment Center/Sleep Diagnosis and Treatment Center,Kangning Hospital Affiliated to Wenzhou Medical University,Wenzhou325000,China;School of Psychiatry,Wenzhou Medical University,Wenzhou 325035,China;Renji College,Wenzhou Medical University,Wenzhou325035,China)

机构地区：[1]温州医科大学附属康宁医院抑郁症诊疗中心睡眠诊疗中心,浙江温州325000 [2]温州医科大学精神医学学院,浙江温州325035 [3]温州医科大学仁济学院,浙江温州325035

出　　处：《中国现代医生》2020年第17期80-83,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2017RC027);浙江省温州市公益性社会发展(医疗卫生)科技项目(Y20160255)。

摘　　要：目的探讨血清胆固醇含量对抑郁障碍患者认知功能的影响。方法本研究纳入2015年7月~2017年2月期间在我院住院的66例抑郁障碍患者,分为较高胆固醇组和较低胆固醇组,均进行重复性成套神经心理状态测验(RBANS)和威斯康辛卡片测验(WCST)。结果①较高胆固醇组的RBANS总分、注意力、言语功能、视觉广度、即刻记忆和延时记忆各因子得分高于较低胆固醇组,差异有统计学意义(P<0.05)。②较高胆固醇组在WCST中的选择错误率、完成第一个分类所需应答数、持续性错误数、持续性错误率、非持续性错误数和非持续性错误率的得分均低于较低胆固醇组,差异有统计学意义(P<0.05);在完成分类数、总应答数、正确应答数、概念化水平百分数均显著高于较低胆固醇组,差异有统计学意义(P<0.05)。结论抑郁障碍患者中较高胆固醇组的认知功能优于较低胆固醇组,胆固醇对抑郁障碍患者的认知功能有保护作用。Objective To explore the effect of serum cholesterol content on cognitive function in patients with depression disorder.Methods 66 patients with depressive disorder who were admitted to our hospital from July 2015 to February 2017 were selected as study subjects.They were divided into a higher cholesterol group and a lower cholesterol group,and they were all received repeatable battery for the assessment of neuropsychological status(RBANS)and Wsiconsin card sorting test(WCST).Results①The scores of RBANS,attention,speech function,visual breadth,immediate memory and delayed memory of the higher cholesterol group were higher than those of the lower cholesterol group,and the differences were statistically significant(P<0.05).②In WCST,the scores of selection error rate,response number required to complete the first classification,persistent error number,persistent error rate,non-persistent error number and non-persistent error rate of the higher cholesterol group were all lower than those of the lower cholesterol group,and the differences were statistically significant(P<0.05);the number of completed classifications,the total number of responses,the number of correct responses,and the percentage of conceptualization levels were significantly higher than those of the lower cholesterol group,and the differences were statistically significant(P<0.05).Conclusion In patients with depression disorder,the cognitive function of the higher cholesterol patients is better than that of the lower cholesterol patients,and cholesterol play a protective role in the cognitive function of patients with depression disorder.

关 键 词：抑郁障碍 总胆固醇 重复性成套神经心理状态测验(RBANS) 威斯康辛卡片测验(WCST) 

分 类 号：R749.4[医药卫生—神经病学与精神病学]