低频重复经颅磁刺激治疗亚急性期卒中后非流利性失语疗效观察  

Observation on the efficacy of low frequency repetitive transcranial magnetic stimulation in the treatment of non-fluent aphasia after subacute stroke

作　　者：瞿砚舟[1] 钟根龙 吕锦[1] 蓝丽康[1] QU Yanzhou;ZHONG Genlong;LV Jin;LAN Likang(Department of Neurology,Lishui People's Hospital in Zhejiang Province,Lishui323000,China)

机构地区：[1]浙江省丽水市人民医院神经内科,浙江丽水323000

出　　处：《中国现代医生》2020年第17期112-115,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2019RC318)。

摘　　要：目的观察低频重复经颅磁刺激(rTMS)治疗亚急性期卒中后非流利性失语的疗效。方法选取我院神经科和康复科2018年8月~2019年7月收治的40例卒中后非流利性失语患者,随机分为治疗组20例和对照组20例。两组患者均进行常规的药物治疗及语言康复训练;治疗组以1 Hz低频rTMS刺激非优势半球Broca区,对照组以相同位点给予rTMS伪刺激;疗程2周。治疗前后评估西部失语症成套检验(WAB)、失语指数(AQ)及美国国立卫生研究院卒中量表(NIHSS)。结果治疗后,两组患者AQ、NIHSS评分均有改善,治疗组对比对照组AQ(53.05±18.75分vs 43.04±10.13分)、NIHSS(4.70±1.92分vs 6.50±2.28分)改善程度更高,差异有统计学意义(P<0.05)。结论低频重复经颅磁刺激可改善亚急性期卒中后非流利性失语患者的语言功能。Objective To observe the efficacy of low frequency repetitive transcranial magnetic stimulation(rTMS)in the treatment of non-fluent aphasia after subacute stroke.Methods 40 patients with non-fluent aphasia after stroke who were treated in the department of neurology and the department of rehabilitation from August 2018 to July 2019 were selected and randomly divided into the treatment group(20 cases)and the control group(20 cases).Patients in both groups were given conventional medication and speech rehabilitation training.The treatment group was given stimulation on the non-dominant hemisphere Broca area with low frequency rTMS at 1 Hz.The control group was given rTMS pseudostimulation at the same site;the course of treatment was 2 weeks.Before and after treatment,the Western Aphasia Battery(WAB),Aphasia Quotient(AQ),and National Institutes of Health Stroke Scale(NIHSS)were evaluated.Results After treatment,the AQ and NIHSS scores in both groups of patients were improved.Compared with the control group,the AQ(53.05±18.75 points vs 43.04±10.13 points)and the NIHSS(4.70±1.92 points vs 6.50±2.28 points)had a higher degree of improvement,and the difference was statistically significant(P<0.05).Conclusion Low frequency repetitive transcranial magnetic stimulation can improve the language function of patients with non-fluent aphasia after subacute stroke.

关 键 词：失语 卒中 亚急性期 重复经颅磁刺激 西部失语症成套检验 失语指数 BROCA区 非优势半球 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749[医药卫生—临床医学]