高强度超声聚焦治疗子宫肌瘤效果及对雌激素受体、Bcl-2蛋白影响  

The effect of high intensity focused ultrasound for treating patients with uterine fibroids and its influence on their levels of estrogen receptor and Bcl-2

作　　者：李婷婷 王嘉昆 陆佳红[2] LI Tingting;WANG Jiakun;LU Jiahong(Taizhou Women and Children Hospital, Zhejiang, 318000;The First People’s Hospital of Xiaoshan District)

机构地区：[1]浙江省台州市妇女儿童医院,318000 [2]浙江省杭州市萧山区第一人民医院

出　　处：《中国计划生育学杂志》2020年第5期760-762,766,共4页Chinese Journal of Family Planning

基　　金：浙江省自然科学基金(No:LQ17H160017)。

摘　　要：目的:评估高强度超声聚焦(HIFU)治疗子宫肌瘤临床效果。方法:选取2016年7月-2019年7月本院收治的56例子宫肌瘤患者,均给予HIFU治疗,在治疗前后对患者进行症状评分、健康相关生活质量(UFS-QOL)问卷评分,测量子宫肌瘤体积,检测患者免疫相关指标、分析雌激素受体(ER)、Bcl-2蛋白变化。结果:与治疗前相比,56例HIFU治疗后1、3、6、12个月子宫肌瘤的体积(21.72±3.65 cm^3、13.42±2.38 cm^3、8.72±1.87 cm^3、5.72±1.02 cm^3)逐渐减小(P<0.05),症状评分(16.26±3.95分、14.13±2.05分、8.84±1.21分、5.03±0.62分)逐渐下降,UFS-QOL评分(82.65±7.02分、87.04±7.86分、93.87±8.75分、98.02±9.54分)逐渐增高,(P<0.05)。治疗后1个月的免疫相关指标CD3^+、CD4^+、CD8^+、CD4^+/CD8^+及NK均高于治疗前,ER、Bcl-2蛋白表达水平低于治疗前(P<0.05)。结论:采用高强度超声聚焦治疗子宫肌瘤,可明显缩小肿瘤的体积,改善患者临床症状并提高生活质量。Objective:To evaluation of the clinical efficacy of high intensity focused ultrasound(HIFU)of patients with uterine fibroids.Methods:56 patients with uterine fibroids were treated by HIFU from July 2016 to July 2019.Before and after treatment,the symptom scores and the scores of health-related quality of life(UFS-QOL)of these patients were evaluated by questionnaires,their volumes of uterine fibroid were measured,their levels of immune-related indicators were detected,and the change of estrogen receptor(ER)and Bcl-2 levels of the patients were analyzed.Results:The volume of uterine fibroids of the patients 1,3,6 and 12 months after treatment were 21.72±3.65cm^3,13.42±2.38cm^3,8.72±1.87cm^3,and 5.72±1.02 cm^3,respectively,which had decreased gradually(P<0.05).The symptom scores of the patients 1,3,6 and 12 months after treatment were 16.26±3.95 points,14.13±2.05 points,8.84±1.21 points,and 5.03±0.62 points,respectively,which had decreased gradually(P<0.05).The score of UFS-QOL of the patients at 1,3,6 and 12 months after treatment were 82.65±7.02 points,87.04±7.86 points,93.87±8.75 points,98.02±9.54 points,respectively,which had increased gradually(P<0.05).1 month after treatment,the immune-related indicators,such as the levels of CD3^+,CD4^+,CD8^+,CD4^+/CD8^+,and NK of patients were all significant higher than those before treatment,but the levels of estrogen receptor ER and bcl-2 expression were significant lower than before treatment(P<0.05).Conclusion:High intensity focused ultrasound for treating patients with uterine fibroids can reduce the volume of the tumor significantly,can alleviate the clinical symptoms,and can improve the quality of life of patients.

关 键 词：子宫肌瘤 高强度超声聚焦 雌激素受体 BCL-2蛋白 

分 类 号：R737.33[医药卫生—肿瘤]