补肾活血法改善乳腺癌认知功能下降的临床观察  

Clinical Observation on the Method of Tonifying the Kidney and Promoting Blood Circulation to Improve the Declining Cognitive Breast Cancer

作　　者：薛娜[1] 徐咏梅[1] 李琦炜 翟孟浩 韩冬[1] 许炜茹[1] 刘声[1] 于明薇[1] 张青[1] 杨国旺[1] XUE Na;XU Yongmei;LI Qiwei;ZHAI Menghao;HAN Dong;XU Weiru;LIU Sheng;YU Mingwei;ZHANG Qing;YANG Guowang(Oncology Department,Beijing Chinese Medicine Hospital,Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院肿瘤科,北京100010

出　　处：《世界中医药》2020年第15期2280-2284,共5页World Chinese Medicine

基　　金：首都卫生发展科研专项(2018-3-2231);北京市科技计划项目(Z171100001017254)。

摘　　要：目的:探讨补肾活血方药治疗化疗后认知功能下降乳腺癌患者的临床疗效。方法:选取2015年11月至2017年11月首都医科大学附属北京中医医院收治的化疗后不同程度认知障碍的乳腺癌患者72例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组36例。对照组给予对应的安慰剂,观察组给予补肾活血为主的方药,均为2次/d,共治疗6周。分别在治疗前后观察2组患者的认知功能(蒙特利尔量表、FACT量表)、生命质量、中医症候评分等。结果:在认知功能评价中,药物观察组患者蒙特利尔量表评分治疗后较治疗前显著提高(P<0.05),与对照组比较也有明显提高(P<0.05)。中药观察组患者的FACT-cog量表积分治疗后较治疗前有显著提高(P<0.05),且与对照组比较有显著提高(P<0.05)。观察组治疗后中医证候评分较治疗前及对照组治疗后均明显提高(P<0.05),观察组与对照组治疗前后的生命质量评分差异无统计学意义(P>0.05)。结论:补肾活血中药一定程度上可以有效改善乳腺癌患者化疗后导致的认知功能下降,但对生命质量的改善并不明显。Objective:To explore the clinical efficacy of Bushen Huoxue Formula on cognitive impairment for patients with breast cancer.Methods:A total of 72 patients with breast cancer of different cognitive degree admitted to Beijing Chinese Medicine Hospital,Capital Medical University,were randomly divided into an observation group and a control with 36 cases in each group.The control group was given placebo while the treatment group was treated mainly with the method of tonifying the kidney and activating blood circulation formulas.Both groups were treated 2 times a day for 6weeks.Cognitive function(Montreal scale,FACT scale),the quality of life and TCM symptom score of the 2 groups before and after treatment were observed.Results:In the evaluation of cognitive function,the Montreal cognitive evaluation in the drug observation group was significantly higher than that of the pre-treatment level(P<0.05).Compared with the control group,the score was significantly increased(P<0.05).The FACT-cog scale scores of the patients in the traditional Chinese medicine observation group were significantly improved after treatment compared with before treatment(P<0.05),and compared with the control group(P<0.05).The scores of TCM syndromes in the observation group after treatment were significantly higher than those before and after treatment in the control group(P<0.05).There was no significant difference in the quality of life scores between the observation group and the control group before and after treatment(P>0.05).Conclusion:To a certain extent,Chinese medicine for invigorating the kidney and promoting blood circulation can effectively improve the cognitive function decline of breast cancer patients after chemotherapy,but it does not significantly improve the overall quality of life.

关 键 词：补肾活血法 中医药 乳腺癌 化疗 认知功能 中医症候 生命质量 临床研究 

分 类 号：R737.9[医药卫生—肿瘤]