基于富集分析的乳腺癌发病相关通路探讨  

Exploration of Pathways Related to Breast Cancer Based on Enrichment Analysis

作　　者：葛杰[1] 贾月辉[1] 李继媛[2] 王琪[3] 韩云峰[1] 谢志平[1] 杨晓蕾[4] 郑毅[5] GE Jie;JIA Yue-hui;LI Ji-yuan;WANG Qi;HAN Yun-feng;XIE Zhi-ping;YANG Xiao-lei;ZHENG Yi(Department of Epidemiology and Health Statistics,Qiqihar Medical College,Qiqihar,Heilongjiang Province,161006 China;Experimental Teaching Center of Qiqihar Medical College,Qiqihar,Heilongjiang Province,161006 China;Department of Immunology,Qiqihar Medical College,Qiqihar,Heilongjiang Province,161006 China;Department of Preventive Medicine,Qiqihar Medical College,Qiqihar,Heilongjiang Province,161006 China;Department of General Medicine,Qiqihar Medical College,Qiqihar,Heilongjiang Province,161006 China)

机构地区：[1]齐齐哈尔医学院流行病与卫生统计学教研室,黑龙江齐齐哈尔161006 [2]齐齐哈尔医学院实验教学中心,黑龙江齐齐哈尔161006 [3]齐齐哈尔医学院免疫学教研室,黑龙江齐齐哈尔161006 [4]齐齐哈尔医学院预防医学教研室,黑龙江齐齐哈尔161006 [5]齐齐哈尔医学院全科医学教研室,黑龙江齐齐哈尔161006

出　　处：《系统医学》2020年第11期29-33,共5页Systems Medicine

基　　金：黑龙江省教育厅面上项目(2016-KYYWF-0885)。

摘　　要：目的从通路水平探讨乳腺癌发病的相关基因。方法使用i-GSEA4GWASv2和ICSNPathway对GRASPv2.0中乳腺癌的GWAS数据进行基因富集分析,有意义的GO通路依照GO数据库注释构建有向无环图。结果与乳腺癌发生有关的4条通路:小GTP酶介导的信号转导(P平均=0.002;FDR平均=0.017)、GnRH信号通路(P_(平均)=0.005;FDR_(平均)=0.041)、MAPK信号通路(P_(平均)=0.001;FDR_(平均)=0.026)、长时程增强通路(P_(平均)=0.002;FDR_(平均)=0.025)。结论为乳腺癌发病机制从小GTP酶信号转导、刺激信号传递、性腺激素释放激素方面提供了新的思路。Objective To explore the genes related to breast cancer at the pathway level.Methods Gene enrichment analysis of breast cancer GWAS data in GRASPv2.0 was performed using i-GSEA4GWASv2 and ICSNPathway.Directed acyclic graphs were constructed according to GO database annotations.Results Four pathways related to breast cancer:small GTPase-mediated signal transduction(Paverage=0.002;FDR average=0.017),GnRH signal pathway(Paverage=0.005;FDR average=0.041),MAPK signal pathway(Paverage=0.001;FDRaverage=0.026),long-term enhancement pathway(Paverage=0.002;FDRaverage=0.025).Conclusion It provides new ideas for breast cancer pathogenesis from small GTPase signal transduction,stimulation signal transmission,and gonadotropin releasing hormone.

关 键 词：富集分析 乳腺癌 通路分析 

分 类 号：R36[医药卫生—病理学]