住院心境障碍患者的碳酸锂缓释片服用剂量与血锂浓度的研究  

Dose and concentration of lithium carbonate sustained release tablets in inpatients with mood disorders

作　　者：蔡璐遥 孙燕茹 杨海晨[3] 方贻儒[2] 刘铁榜[3] CAI Lu-yao;SUN Yan-ru;YANG Hai-chen;FANG Yi-ru;LIU Tie-bang(Anhui Medical University,Shenzhen mental health center,Shenzhen 518000,China)

机构地区：[1]安徽医科大学深圳精神卫生学院,518000 [2]上海市精神卫生中心 [3]深圳市精神卫生中心

出　　处：《临床精神医学杂志》2020年第4期230-233,共4页Journal of Clinical Psychiatry

基　　金：深圳市医疗卫生三名工程资助项目(SZSM201612006)。

摘　　要：目的:探讨住院心境障碍患者碳酸锂服用剂量与血锂浓度的关系,以及对患者的疗效及药物不良反应。方法:采用回顾性研究方法,对120例住院心境障碍患者使用碳酸锂缓释剂的数据进行分析。结果:最终入组113例(94.17%)住院心境障碍患者,碳酸锂缓释片使用剂量为0.9~1.2 g/d,而且在剂量范围的血锂浓度为0.71~0.82 mmol/L。在相同的口服剂量下,体质量越小的患者,其血锂浓度越高。4例出现呕吐感,7例出现双上肢震颤的不良反应。药物显效率69.17%,总有效率96.67%。结论:对住院心境障碍患者,碳酸锂缓释片口服剂量0.9~1.2 g/d是安全、有效的剂量范围。Objective:To investigate the relationship between dose of lithium carbonate and blood lithium concentration in inpatients with mood disorders,and its efficacy and side effects.Method:A retrospective study was conducted in 120 inpatients with mood disorders treated with lithium carbonate sustained-release agent.Results:In 113(94.17%)inpatients with mood disorders,the dose of lithium carbonate sustained release tablets was 0.9-1.2 g/d.The mean blood lithium concentration range of inpatients in this dose range was 0.71-0.82 mmol/L.At the same oral dose,the lower the body weight,the higher the lithium concentration.There were 4 cases of vomiting sense and 7 cases of upper limbs tremor.The excellent efficacy of treatment was 69.17%,and the total efficacy was 96.67%.Conclusion:For the inpatients with mood disorders,oral dose of lithium carbonate sustained release 0.9-1.2 g/d is a safe and effective dose range.

关 键 词：心境障碍 碳酸锂 剂量 浓度 疗效 

分 类 号：R749.4[医药卫生—神经病学与精神病学]