超声BI-RADS联合血CA15-3和CEA在乳腺肿物诊断中的价值研究  

Research on the value of ultrasound BI-RADS combined with serum CA15-3 and CEA in the diagnosis of breast tumors

作　　者：刘思奇 边娜娜 苏亚娟[1] LIU Siqi;BIAN Nana;SU Yajuan(Department of Clinical Laboratory,Harbin Medical University Cancer Hospital,Harbin 150081,China;Department of Cardiopulmonary Function Examination Room,Harbin Medical University Cancer Hospital)

机构地区：[1]哈尔滨医科大学附属肿瘤医院临床检验科,哈尔滨150081 [2]哈尔滨医科大学附属肿瘤医院心肺功能科

出　　处：《实用肿瘤学杂志》2020年第4期347-351,共5页Practical Oncology Journal

摘　　要：目的探讨超声BI-RADS与血CA15-3和CEA联合检测在乳腺肿物中的诊断价值。方法选择2019年6月—2019年12月乳腺肿物患者111例,以病理结果为金标准,分析超声BI-RADS、血CA15-3和CEA联合对乳腺肿物诊断的敏感性及准确性。结果病理示良性病变43例,乳腺癌68例。与良性病变患者相比,乳腺癌患者血CA15-3和CEA均升高(P<0.05)。乳腺癌患者CA15-3和CEA呈正相关。超声BI-RADS、血CA15-3和CEA联合对乳腺癌诊断的敏感性达到73.5%,准确性升高至83.8%,AUC提高到0.957,均高于三者各自单独使用时的诊断效果。结论超声BI-RADS、血CA15-3和CEA联合检测是一种提高乳腺肿物诊断敏感性和准确率的有效方法。Objective The aim of this study was to investigate the diagnostic value of ultrasound BI-RADS combined detection with serum CA15-3 and CEA in breast tumors.Methods A total of 111 patients with breast tumors from June 2019 to December 2019 were selected.The pathological results were used as the gold standard to analyze the sensitivity and accuracy of ultrasound BI-RADS,serum CA15-3 and CEA in the diaganosis of breast tumor.Results Pathological results showed 43 cases of benign lesions and 68 cases of breast cancer.Compared with patients with benign lesions,the increase in serum CA15-3 and CEA in breast cancer patients was statistically different.There was also a positive correlation between the increase of CA15-3 and CEA with breast cancer.By combining ultrasound BI-RADS with serum CA15-3 and CEA,the sensitivity for breast cancer diagnosis reached 73.5%,the accuracy increased to 83.8%,and the AUC of the ROC curve was increased to 0.957,which was higher than the results when they were used alone.Conclusion The combined detection of ultrasound BI-RADS,serum CA15-3 and CEA is an effective method to improve the sensitivity and accuracy of breast tumor diagnosis.

关 键 词：乳腺癌 超声检查 糖类抗原15-3 癌胚抗原 

分 类 号：R737.9[医药卫生—肿瘤]