外周淋巴细胞亚群分布与前列腺癌并多原发癌关系的病例对照研究  

Case-control study on the distribution of peripheral lymphocyte subsets and multiple primary cancers with prostate cancer

作　　者：王俊[1] 荆翌峰[1] 韩邦旻[1] WANG Jun;JING Yifeng;HAN Bangmin(Department of Urology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200080,China)

机构地区：[1]上海交通大学附属第一人民医院泌尿外科,上海200080

出　　处：《临床泌尿外科杂志》2020年第6期423-425,430,共4页Journal of Clinical Urology

摘　　要：目的:探索外周淋巴细胞亚群分布对前列腺癌并多原发癌发生的影响。方法:对经病理确诊的包含前列腺癌的多原发癌44例及同期单纯前列腺癌患者,应用年龄、Gleason总评分、主要评分、次要评分加权、病理临床分期、BMI、饮酒史和吸烟史的倾向性评分按1:4配比设立对照组(176例),利用单因素和多因素Logistic回归分析外周淋巴细胞亚群对前列腺癌并多原发癌发病的影响。结果:单纯前列腺癌组与前列腺癌并多原发癌组的患者首次确诊年龄、Gleason总评分、2014年国际泌尿病理协会(ISUP)前列腺癌预后分组和PSA水平无显著性差异。单因素分析显示CD3+、CD4+CD29+、CD8+CD28+、CD4+CD25+/CD4+、CD3-CD(16+56)+、CD3+CD4+CD8-与前列腺癌并多原发癌发生有明确的统计学关系,OR分别为0.96、0.95、0.90、1.26、1.04、0.95,P<0.05。通过多元逐步回归,排除部分变量,仅保留CD3-CD(16+56)+、CD4+CD25+/CD4+进入多因素Logistic回归。CD3-CD(16+56)+、CD4+CD25+/CD4+在多因素分析中OR分别为1.04、1.24,P<0.05差异有统计学意义。结论:CD4+CD25+、CD3-CD(16+56)+亚群淋巴细胞的升高与前列腺癌并多原发癌的发生相关,可能是前列腺癌并多原发癌的独立危险因素。Objective: To explore the association between peripheral lymphocyte subsets and multiple primary cancers with prostate cancer. Method: Forty-four cases of multiple primary cancers with prostate cancer were identified. One hundred and seventy-six patients with simple primary prostate cancer at same periods were selected as the matched control group with propensity score based on age, Gleason total score, predominant score, secondary score, pathological clinical stage, body mass index, drinking history and smoking history. Univariate and multivariate logistic regression were used to analyze the association between peripheral lymphocyte subsets and multiple primary cancers with prostate cancer. Result: There was no significant difference in the age of diagnosis, Gleason total score, ISUP2014 group or PSA level between the prostate cancer group and the prostate cancer-related multiple primary cancer group. Univariate analysis showed that CD3+, CD4+CD29+, CD8+CD28+, CD4+CD25+/CD4+, CD3-CD(16+56)+, and CD3+CD4+CD8-had a clear statistical association with multiple primary cancers with prostate cancer(OR: 0.96, 0.95, 0.90, 1.26, 1.04, and 0.95, respectively, P<0.05). Multivariate stepwise regression, excluding redundant variables, only retained CD3-CD(16+56)+ and CD4+CD25+/CD4+ into multivariate logistic regression. CD3-CD(16+56)+ and CD4+CD25+/CD4+ had OR of 1.04 and 1.24 in multiple regressions(P<0.05). Conclusion: The elevation of CD4+CD25+ and CD3-CD(16+56)+ subpopulation lymphocytes is associated with the occurrence of multiple primary cancers with prostate cancer, and this may be an independent risk factor of multiple primary cancers with prostate cancer.

关 键 词：前列腺癌 多原发癌 外周淋巴细胞亚群 

分 类 号：R737.25[医药卫生—肿瘤]