CC趋化因子受体因子4在年轻乳腺癌患者中的表达及与临床预后的相关性研究  

Expression of CC Chemokine Receptor Factor 4 in Young Breast Cancer Patients and Its Correlation with Clinical Prognosis

作　　者：黄其文[1] 莫慧[1] 黎新喜 HUANG Qi-wen;MO Hui;LI Xin-xi(Department of Pathology,Maoming People's Hospital,Maoming,Guangdong Province,525000 China)

机构地区：[1]茂名市人民医院病理科,广东茂名525000

出　　处：《世界复合医学》2020年第6期113-115,共3页World Journal of Complex Medicine

基　　金：2017年茂名市第一批(医疗卫生类)科技计划立项(2017244)。

摘　　要：目的探究CC趋化因子受体因子4(CCR4)在年轻乳腺癌患者中的表达及与临床预后的相关性。方法统计该院2014年1月—2015年12月间的乳腺癌患者(剔除新辅助化疗及资料不全患者)的临床病理资料,选取年轻乳腺癌患者(<35岁)、非年轻乳腺患者(≥35岁)各自50例,将其分为年轻组与非年轻组。要求标本组织块带癌组织及癌旁正常乳腺组织,采用免疫组织化学检测癌组织及癌旁正常乳腺组织中CCR4的表达,探讨CCR4表达与年轻乳腺癌患者及其预后分析。结果年轻组与非年轻组在CCR4表达上,乳腺癌组织表达率均比癌旁组织高(P<0.05),而年轻组的CCR4高表达率(58.00%)显著比非年轻组(44.00%)高(P<0.05),年轻组的肿瘤组织学分级、肿瘤直径、淋巴结转移的CCR4高表达率显著比非年轻组高(P<0.05),根据CCR4蛋白表达情况,将年轻组患者分为CCR4阳性组和CCR4阴性组,Kaplan-Meier分析结果显示,两组之间无瘤生存期(DFS)差异有统计学意义(P<0.05)。结论CCR4在年轻乳腺癌患者中呈高表达,其与乳腺癌患者预后呈正相关,CCR4参与到乳腺癌的发生发展中。Objective To explore the expression of CC chemokine receptor factor 4(CCR4)in young breast cancer patients and its correlation with clinical prognosis.Methods The clinical and pathological data of breast cancer patients(excluding neoadjuvant chemother-apy and patients with incomplete data)from January 2014 to December 2015 in the hospital were counted.50 young breast cancer patients(<35 years old)and non-young breast patients(≥35 years old)were selected.For example,divide it into a young group and a non-young group.Specimens were required to carry cancer tissues and normal breast tissues adjacent to cancer.Immunohistochemistry was used to detect the expression of CCR4 in cancer tissues and normal breast tissues adjacent to cancer,and to explore CCR4 expression and young breast cancer patients and their prognostic analysis.Results The expression rates of CCR4 in the young group and non-young group were higher than those in the adjacent tissues(P<0.05),while the high expression rate of CCR4 in the young group(58.00%)was significantly higher than that in the non-young group(44.00%)(P<0.05),the CCR4 high expression rate of tumor histology grade,tumor diameter,and lymph node metastasis of the young group was significantly higher than that of the non-young group(P<0.05).According to the CCR4 protein expression,the young group of patients were divided into CCR4-positive group and CCR4-negative group.Kaplan-Meier analysis showed that the difference in tumor-free survival(DFS)between the two groups was statistically significant(P<0.05).Conclusion CCR4 is highly expressed in young breast cancer patients,which is positively correlated with the prognosis of breast cancer patients.CCR4 is involved in the occurrence and development of breast cancer.

关 键 词：CC趋化因子受体因子4 表达 预后 乳腺癌 相关性 

分 类 号：R737.9[医药卫生—肿瘤]