口腔黏膜下纤维性变的成因及癌变的相关性研究  

Etiology and Malignant Transformation of Oral Submucous Fibrosis:A Review

作　　者：翦新春[1] 高兴[1] 谭茜 JIAN Xinchun;GAO Xing;TAN Qian(Department of Oral and Maxillofacial Surgery,Center of Stomatology,Xiangya Hospital,Central South University,Institute of Oral Precancerous Lesions,Central South University,Changsha 410008,Hunan Province,China)

机构地区：[1]中南大学湘雅医院口腔医学中心口腔颌面外科,中南大学口腔癌前病变研究所,湖南长沙410008

出　　处：《口腔颌面外科杂志》2020年第4期195-200,共6页Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金项目(81260166、81041052、30572044)。

摘　　要：口腔黏膜下纤维性变(oral submucous fibrosis,OSF)是世界卫生组织(World Health Organization,WHO)国际癌症研究中心(International Agency for Research on Cancer,IARC)认定的口腔黏膜潜在的恶性病变。咀嚼槟榔可引起口腔黏膜下纤维性变,其发病与咀嚼槟榔的频率及时间有着密切的量效依赖关系。本文就口腔黏膜下纤维性变是否是一种口腔癌前病变,咀嚼槟榔导致口腔黏膜潜在的恶性病变,以及国外、中国大陆与台湾地区有关该病的研究作一概述,供口腔科医师参考。Oral submucous fibrosis(OSF)was defined as an oral potentially malignant mucous disorders by the International Agency for Research on Cancer(IARC)of the World Health Organization(WHO).Oral submucous fibrosis was led by chewing betel quid and showed a dose-dependent and time-dependent manner.Whether oral submucous fibrosis is a real oral precancerous lesion or oral potentially malignant disorders led by chewing betel quid,this paper summarizes the present knowledge throughout the foreign countries,Chinese mainland,and Taiwan.

关 键 词：口腔黏膜下纤维性变 口腔黏膜潜在恶性病变 口腔癌前病变 

分 类 号：R782[医药卫生—口腔医学] R739.8[医药卫生—临床医学]