肠道菌群与妇科恶性肿瘤关系的研究进展  

Progress on the relationship between gut microbiome and gynecologic malignancies

作　　者：何昕晖 宫婷婷[2] 马晓欣[2] 高嵩[2] 李秀琴[2] 赵玉虹[1] 吴琪俊[1] He Xinhui;Gong Tingting;Ma Xiaoxin;Gao Song;Li Xiuqin;Zhao Yuhong;Wu Qijun(Department of Clinical Epidemiology,Shengjing Hospital of China Medical University,Shenyang 110004,Chian;Department of Obstetrics and Gynecology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院临床流行病学教研室,沈阳110004 [2]中国医科大学附属盛京医院妇产科,沈阳110004

出　　处：《肿瘤综合治疗电子杂志》2020年第3期1-4,共4页Journal of Multidisciplinary Cancer Management(Electronic Version)

基　　金：科技部国家重点研发计划(2017YFC0907401);国家自然科学基金青年项目(81602918);中国博士后科学基金面上项目(2018M641752);辽宁省“兴辽英才计划”项目(XLYC1907102);沈阳市中青年科技创新人才支持计划(RC190484)。

摘　　要：妇科恶性肿瘤是女性生殖系统常见疾病,主要包括宫颈癌、子宫内膜癌、卵巢癌等,其病因和发病机制尚未完全明确。近年来,随着高通量测序技术、宏基因组学和代谢组学的应用,已有多项研究指出肠道菌群可能在多种妇科肿瘤的发生和发展中发挥重要作用。本文对肠道微生物与妇科恶性肿瘤关系的研究进展予以综述。Gynecologic malignancies are common diseases of the female reproductive system,mainly including cervical cancer,endometrial carcinoma,ovarian cancer,etc.And the etiology and pathogenesis of gynecologic malignancies have not been fully elucidated.In recent years,with the application of high-throughput sequencing technology,metagenomics and metabonomics,studies have pointed out that gut microbiome may play an important role in the occurrence and development of gynecologic malignancies.In this article,the relationship between gut microbiome and gynecologic malignancies are reviewed.

关 键 词：肠道菌群 妇科肿瘤 宫颈癌 子宫内膜癌 卵巢癌 

分 类 号：R737.3[医药卫生—肿瘤]