晚期结直肠癌多模式维持治疗撷英  

Review of maintenance therapy of advanced colorectal cancer

作　　者：朱旭东 张航瑜 傅琦涵 童舟[1] 刘璐璐[1] 郑怡[1] 赵鹏[1] 方维佳[1] Zhu Xudong;Zhang Hangyu;Fu Qihan;Tong Zhou;Liu Lulu;Zheng Yi;Zhao Peng;Fang Weijia(Department of Medical Oncology,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院肿瘤内科三,杭州310003

出　　处：《肿瘤综合治疗电子杂志》2020年第3期69-74,共6页Journal of Multidisciplinary Cancer Management(Electronic Version)

基　　金：国家自然科学基金面上项目(No.81472210);国家自然科学基金青年项目(No.81602128);浙江省重大科技专项(2017C03028)。

摘　　要：在过去的20年里,全身化疗联合靶向药物已成为转移性结直肠癌的标准治疗模式,明显改善了结直肠癌患者的预后。但标准强度持续给药也带来了患者依从性减弱的棘手问题,因此,维持治疗逐渐得到了推广,在减少药物不良反应的同时,提高患者生活质量,改善生存。本文对晚期结直肠癌的主流维持治疗模式的研究进展进行综述。Integrating targeted new drugs with chemotherapy has become the standard treatment for metastasis colorectal cancer(mCRC),and greatly improved the prognosis of mCRC patients during the past 20 years.Nevertheless,continuous combination therapy could also weaken the compliance of patients.Therefore,maintenance treatment has gradually been promoted,while reducing adverse drug reactions,improving the quality of life of patients and improving survival.This article reviews the research progress of mainstream maintenance treatment models for advanced colorectal cancer.

关 键 词：结直肠癌 维持治疗 化疗 靶向治疗 免疫治疗 

分 类 号：R735.34[医药卫生—肿瘤]