两种不同的麻醉用药方法在老年肺癌患者手术治疗中的应用效果观察  

Observation on the effect of two different anesthesia methods in the surgical treatment of elderly lung cancer patients

作　　者：李文静[1] 胡义凤[1] 朱敏敏[1] 沈卫红[1] Li Wenjing;Hu Yifeng;Zhu Minmin;Shen Weihong(Department of Anesthesiology,Wuxi Second People's Hospital,Wuxi,Jiangsu,214000,China)

机构地区：[1]无锡市第二人民医院麻醉科,江苏无锡214000

出　　处：《当代医学》2020年第23期19-21,共3页Contemporary Medicine

摘　　要：目的研究老年肺癌患者在手术治疗过程中应用两种不同麻醉用药方法的效果。方法选取2017年8月至2019年8月本院接收的40例老年肺癌患者,采用随机抽签法将所有患者分为七氟烷组与丙泊酚组,每组20例。七氟烷组应用七氟烷复合瑞芬太尼、顺式阿曲库铵进行麻醉维持;丙泊酚组应用丙泊酚复合瑞芬太尼、顺式阿曲库铵来进行麻醉维持。比较两组患者的术后疼痛感、认知功能、S100β血清蛋白水平。结果手术前,两组患者的认知功能MMSE评分比较差异无统计学意义;手术后,七氟烷组患者的认知功能水平优于丙泊酚组,两组比较差异具有统计学意义(P<0.05)。手术前,两组患者的疼痛感评分比较差异无统计学意义;手术后,七氟烷组患者的疼痛感评分低于丙泊酚组,两组比较差异具有统计学意义(P<0.05)。手术前,两组患者的S100β血清蛋白水平比较差异具有统计学意义;手术后,七氟烷组患者的S100β血清蛋白水平优于丙泊酚组,两组比较差异具有统计学意义(P<0.05)。结论不同的用药麻醉方法对患者的麻醉效果存在一定的差异,老年肺癌患者在手术治疗过程中应用七氟烷药物进行麻醉效果更佳,可以有效的改善患者的认知功能,改善患者的S100β血清蛋白水平,减轻患者的术后疼痛感,值得临床推广应用。Objective To study the effect of two different anesthesia methods on the elderly patients with lung cancer during the operation.Methods A total of 40 elderly lung cancer patients received by our hospital from August 2017 to August 2019 were selected, and all patients were divided into sevoflurane group and propofol group by random drawing, with 20 cases in each group. Sevoflurane group used sevoflurane combined with remifentanil and CIS atracurium for anesthesia maintenance, propofol group used propofol combined with remifentanil and CIS atracurium for anesthesia maintenance. The pain, cognitive function and S100 β serum protein levels of the two groups were compared. Results Before the operation, there was no statistically significant difference in the cognitive function MMSE scores between the two groups;after the operation, the cognitive function level of the sevoflurane group was better than the propofol group, and the difference between the two groups was statistically significant(P<0.05). Before surgery, there was no statistically significant difference in pain score between the two groups;after surgery, the pain score of the sevoflurane group was lower than that of the propofol group, and the difference between the two groups was statistically significant(P<0.05). Before surgery, there was no statistically significant difference in S100β serum protein level between the two groups, after surgery, the S100β serum protein level in the sevoflurane group was better than the propofol group, and the difference between the two groups was statistically significant(P<0.05). Conclusion There is some difference in the anesthesia effect of different anesthesia methods for patients, sevoflurane is better for the elderly lung cancer patients in the process of surgical treatment. It can effectively improve the cognitive function of patients, improve the S100 β serum protein level of patients, reduce the postoperative pain of patients, worth clinical promotion.

关 键 词：老年肺癌患者 不同的麻醉用药方法 效果 观察 七氟烷 丙泊酚 

分 类 号：R734.2[医药卫生—肿瘤] R614[医药卫生—临床医学]