老年急性脑梗死患者预后与超敏C反应蛋白相关性研究  

Correlation between prognosis and hypersensitive C-reactive protein in elderly patients with acute cerebral infarction

作　　者：刘磊[1] 张燕辉[1] 冯研[1] 杨兴东[1] 史冬梅[1] 于逢春[1] 李小刚[2] LIU Lei;ZHANG Yan-hui;FENG Yan;YANG Xing-dong;SHI Dong-mei;YU Feng-chun;LI Xiao-gang(Department of Neurology,Beijing Haidian Hospital,Beijing 100086,China;Department of Neurology,Peking University Third Hospital,Beijing 100086,China)

机构地区：[1]北京市海淀医院神经内科,北京100086 [2]北京大学第三医院神经内科,北京100086

出　　处：《临床军医杂志》2020年第6期676-678,共3页Clinical Journal of Medical Officers

摘　　要：目的探讨老年急性脑梗死患者发病3个月预后与超敏C反应蛋白(hs-CRP)的相关性。方法选取2018年1—12月北京市海淀医院收治的老年急性脑梗死患者112例为研究对象。根据改良Rankin量表将患者分为A组(0分≤mRS≤2分,n=94)与B组(3分≤mRS≤6分,n=18)。比较两组患者一般资料与相关化验指标。采用多因素Logistic回归分析法分析老年急性脑梗死患者预后不良的独立危险因素。结果B组患者入院时的美国国立卫生研究院卒中量表(NIHSS)评分与hs-CRP水平显著高于A组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,血清hs-CRP水平升高、入院时NIHSS评分升高是老年急性脑梗死预后不良的独立危险因素(P<0.05)。结论监测血清hs-CRP水平可预判急性脑梗死患者预后情况,为临床治疗提供参考依据。Objective To investigate the correlation between the prognosis of elderly patients with acute cerebral infarction and hypersensitive C-reactive protein(hs-CRP).Methods A retrospective study was performed on 80 patients with acute cerebral infarction who were admitted from January to December 2018.According to the modified Rankin scale,patients were divided into Group A(0≤mRS≤2,n=94)and Group B(3≤mRS≤6,n=18).The general data of the two groups of patients were compared with the relevant laboratory indicators.Multivariate Logistic regression analysis was used to analyze the independent risk factors for poor prognosis in elderly patients with acute cerebral infarction.Results The national institutes of health stroke scale(NIHSS)score and hs-CRP level of patients in Group B at admission were significantly higher than those in Group A,and the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that elevated serum hs-CRP level and elevated NIHSS score at admission were independent risk factors for poor prognosis in elderly patients with acute cerebral infarction(P<0.05).Conclusion The serum hs-CRP level is monitored to predict the prognosis of patients with acute cerebral infarction,so as to provide reference for clinical treatment.

关 键 词：老年急性脑梗死 超敏C反应蛋白 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]