microRNA-胶质细胞调控网络在放射性脑损伤中的研究现状与展望  

The research status and prospects of microRNA-glial regulatory network in radiation-induced brain injury

作　　者：区铭乾 孙芙蓉 范炜豪 崔理立 李敏华 林玫君 余杨生 梁诗韵 周海红 Ou Mingqian;Sun Furong;Fan Weihao;Cui Lili;Li Minhua;Lin Meijun;Yu Yangsheng;Liang Shiyun;Zhou Haihong(Department of Neurology,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China;Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China;Department of Neurology,Puning People's Hospital,Jieyang 515300,China;Department of Otolaryngology,Head and Neck Surgery,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)

机构地区：[1]广东医科大学附属医院神经内科,湛江524001 [2]广东医科大学附属医院广东省衰老相关心脑疾病重点实验室,湛江524001 [3]普宁市人民医院神经内科,揭阳515300 [4]广东医科大学附属医院耳鼻咽喉头颈外科,湛江524001

出　　处：《中华放射医学与防护杂志》2020年第7期564-569,共6页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金(81501040)。

摘　　要：放射性脑损伤(radiation-induced brain injury,RBI)是头颈部肿瘤放射治疗后最为严重的并发症,发病机制复杂,临床病程不可逆且缺乏有效的治疗手段。胶质细胞激活是RBI的主要学说之一,靶向胶质细胞防治RBI是当前研究的热点。microRNA(miRNA)作为一种转录后调控因子,已被证实参与调节胶质细胞辐射敏感性,炎症类型转化,自噬,外泌体,长链非编码RNA(long non-coding RNA,lncRNA)、环状RNA(circular RNA,circRNA)等相关通路,从而介导中枢神经系统(central nervous system,CNS)疾病炎症级联损伤及神经功能修复的发生发展。因此,本文以RBI与miRNA-胶质细胞调控网络的联系为基点,概述了当前可用于防治RBI潜在的通路与方法。Radiation-induced brain injury(RBI)is the most serious complication of head and neck tumor after radiotherapy.The pathogenesis of RBI is complicated,and the clinical course is irreversible,while no effective treatment available.The activation of glial cells is one of the main theories of RBI,and the prevention and treatment of RBI by targeting glial cells is the focus of current research.As a post-transcriptional regulatory factor,microRNA(miRNA)has been confirmed to be involved in regulatingglial cell radiosensitivity,inflammation type transformation,autophagy,exosomatic,long non-coding RNA(lncRNA),circular RNA(circRNA)and other related pathways,thereby mediating the occurrence and development of cascade reaction of inflammatory injury and neurological function repair of central nervous system(CNS)disease.Therefore,the establishment of miRNA-glial regulatory network may provide a new strategy for the prevention and treatment of RBI.

关 键 词：放射性脑损伤 MICRORNA 胶质细胞 调控网络 

分 类 号：R739.91[医药卫生—肿瘤] R730.55[医药卫生—临床医学]