血清可溶性OX40配体与晚期胃癌生存期的关系研究  

Study on the relationship between serum soluble OX40 ligand and the survival of advanced gastric cancer patients

作　　者：刘芳 姜兰斌 汪亮 牛彦锋[2] 肖勇[2] 张万里[2] Liu Fang;Jiang Lanbin;Wang Liang;Niu Yanfeng;Xiao Yong;Zhang Wanli(Department of Clinical Laboratory,Wuhan Red Cross Hospital,Wuhan 430015,China;Department of Abdominal Tumor Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]武汉市红十字会医院(武汉市第十一医院)检验科,武汉430015 [2]华中科技大学同济医学院附属协和医院消化肿瘤外科,武汉430022

出　　处：《中华普通外科学文献（电子版）》2020年第4期290-293,共4页Chinese Archives of General Surgery(Electronic Edition)

基　　金：湖北省自然科学基金项目(WJ2015MB075)。

摘　　要：目的探讨晚期胃癌患者血清可溶性OX40配体(sOX40L)水平与生存期的关系,为胃癌免疫治疗提供思路。方法选取武汉市红十字会医院和华中科技大学同济医学院附属协和医院2015年1月至2017年5月收治的115例晚期胃癌患者为观察组,同期健康体检者91名为对照组。ELISA法检测两组血清sOX40L水平,Kaplan-Meier曲线分析sOX40L水平与晚期胃癌患者生存时间的关系,再行危险因素的Cox回归分析。结果观察组sOX40L水平高于对照组(P<0.05),其中高水平组(sOX40L≥20.58 ng/L)58例,低水平组(sOX40L<20.58 ng/L)57例,sOX40L水平与患者TNM分期、淋巴结转移、肝转移有关(P<0.05)。高水平组的中位总生存时间为6.65个月(95%CI:5.89~7.42),短于低表达组的9.47个月(95%CI:8.59~10.36),差异有统计学意义(P<0.001)。年龄≥60岁、sOX40L高表达、TNMⅣ期、淋巴结转移、肝转移均是晚期胃癌不良预后的独立危险因素(P<0.05)。结论sOX40L在晚期胃癌患者血清中呈高表达,其水平与TNM分期、淋巴结转移、肝转移有关,是胃癌患者不良预后的独立危险因素。Objective To investigate the relationship between serum soluble OX40 ligand(sOX40L)and survival time in patients with advanced gastric cancer and to provide basis for immunotherapy of gastric cancer.Methods From January 2015 to May 2017,115 patients with advanced gastric cancer admitted to Wuhan Red Cross Hospital and Union Hospital of Tongji Medical College were selected as the observation group,and 91 healthy persons in the same period were in the control group.The level of serum sOX40L in two groups was detected by ELISA,Kaplan-Meier curve was used to analyze the relationship between the level of sOX40L and survival time of patients,COX regression analysis was used for risk factors of advanced gastric cancer.Results The level of sOX40L in the observation group was higher than that in the control group(P<0.05).There were 58 cases in high level group(sOX40L≥20.58 ng/L),57 cases in low level group(sOX40L<20.58 ng/L),the level of sOX40L was related to TNM stage,lymph node metastasis and liver metastasis(P<0.05).The median total survival time of high level group was 6.65 months(95%CI:5.89-7.42),which was shorter than 9.47 months of low level group(95%CI:8.59-10.36),the difference was statistically significant(P<0.001).Age≥60 years old,high expression of sOX40L,TNMⅣstage,lymph node metastasis and liver metastasis were independent risk factors for poor prognosis of advanced gastric cancer.Conclusions sOX40L is highly expressed in the serum of patients with advanced gastric cancer,its level is related to TNM stage,lymph node metastasis and liver metastasis.It is an independent risk factor for poor prognosis of patients with gastric cancer.

关 键 词：胃肿瘤 OX40配体 危险因素 生存分析 

分 类 号：R735.2[医药卫生—肿瘤]