尿激酶与rt-PA超早期静脉溶栓疗法在急性脑梗死治疗中的应用价值  

The application value of urokinase and rt-PA ultra-early intravenous thrombolytic therapy in the treatment of acute cerebral infarction

作　　者：张丽 杨伟 ZHANG Li;YANG Wei(Department of Neurology,Yanggu County People's Hospital,Liaocheng 252300,China)

机构地区：[1]山东省阳谷县人民医院神经内科,聊城252300

出　　处：《中华灾害救援医学》2020年第8期426-428,431,共4页Chinese Journal of Disaster Medicine

摘　　要：目的探究尿激酶与rt-PA超早期静脉溶栓疗法在急性脑梗死治疗中的效果。方法选取山东省阳谷县人民医院院2018-02至2019-12期间收治的急性脑梗死患者81例,根据不同用药方法将其分为观察组(n=41)和对照组(n=40),观察组予以重组组织型纤溶酶原激活剂(rt-PA)超早期静脉溶栓,对照组予以尿激酶超早期静脉溶栓,为期21 d,比较两组治疗效果(临床疗效、神经功能缺损程度、日常生活活动能力、并发症)。结果治疗后,研究组治疗总有效率(92.68%)高于对照组(72.05%);研究组美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分低于对照组,但Barthel指数明显高于对照组;研究组并发症发生率(2.44%)低于对照组(15.0%),差异均具有统计学意义(P<0.05)。结论与尿激酶比较,rt-PA超早期静脉溶栓治疗急性脑梗死的效果更优,可有效改善神经功能缺损程度,提高日常生活活动能力,减少并发症,值得优选。Objective To explore the effects of urokinase and rt-PA ultra-early intravenous thrombolytic therapy in the treatment of acute cerebral infarction.Methods 81 patients with acute cerebral infarction admitted to Yanggu County People’s Hospital from February 2018 to December 2019 were selected and divided into observation group (n=41) and control group (n=40) according to different medication methods.The observation group was given reorganized type plasminogen activator (rt-PA) ultra-early intravenous thrombolysis,the control group was treated with urokinase ultra-early intravenous thrombolysis for 21 days.The therapeutic effects of the two groups were compared (clinical efficacy,degree of neurological impairment,activities of daily living,complications).Results After treatment,the total effective rate of treatment in the observation group (92.68%) was higher than that of the control group (72.05%);the National Institute of Health stroke scale (NIHSS) scores of the observation group was lower than that of the control group,but the Barthel index was significantly higher than that of the control group;the complication rate of the study group (2.44%)) was lower than the control group (15.00%),and the differences were statistically significant (P<0.05).Conclusions Compared with urokinase,rt-PA intravenous thrombolysis is more effective in the treatment of acute cerebral infarction,which can effectively improve the degree of neurological deficit,improve the ability of daily life,and reduce complications.

关 键 词：急性脑梗死 超早期静脉溶栓疗法 尿激酶 RT-PA 临床疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]