家畜DGAT1基因的生物学功能及其在遗传育种中的应用研究  

Biological Function of DGAT1 Gene and Its Application in Genetic Breeding in Livestock

作　　者：宋天 王大会 刘贤 安清明 王献伟 茹宝瑞 徐泽君 雷初朝[1] 陈宏[1] 黄永震[1] SONG Tian;WANG Da-hui;LIU Xian;AN Qing-ming;WANG Xian-wei;RU Bao-rui;XU Ze-jun;LEI Chu-zhao;CHEN Hong;HUANG Yong-zhen(College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling, Shaanxi, 712100;College of Agriculture and Forestry Engineering, Tongren Unviersity, Tongren, Guizhou 554300;Henan Provincial Animal Husbandry General Station, Zhengzhou 450008)

机构地区：[1]西北农林科技大学动物科技学院,陕西杨凌712100 [2]铜仁学院农林工程与规划学院,贵州铜仁554300 [3]河南省畜牧总站,郑州450008

出　　处：《中国牛业科学》2020年第4期52-56,共5页China Cattle Science

基　　金：国家肉牛牦牛产业技术体系专项(CARS-37);贵州省科技计划项目(黔科合支撑2018-2277,2018-1161);河南省科技攻关计划项目(2021021102433);河南省肉牛产业技术体系项目(S2013-08)。

摘　　要：DGAT1基因属于酰基辅酶A胆固醇酰基转移酶(acyl CoA:cholesterol acyltransferase,ACAT)基因家族,DGAT1基因催化反应的底物为二酰甘油和乙酰辅酶A(fatty acyl CoAs),该基因一方面参与脂肪的合成,在细胞中起到重要的中心代谢作用,另一方面作为影响家畜泌乳性状和脂肪沉积的重要候选基因,被认为对乳脂合成、脂肪含量和食用价值均有显著影响。本文通过对DGAT1基因的生物学功能、分子结构以及该基因多态性与各类家畜经济性状的关联性进行综述,阐明该基因在家畜发育中的遗传表达规律,并对DGAT1基因在家畜育种方面的研究前景做出展望。DGAT1 gene belonged to the acyl coenzyme A cholesterol acyltransferase(acyl CoA:cholesterol acyltransferase,ACAT)gene family,whose catalytic reaction substrates were diacylglycerol and acetyl-CoA(fatty acyl CoAs).On the one hand,this gene involved in the synthesis of fat,and played an important role in the center metabolism of the cells.On the other hand,as the important candidate genes that affected the lactation traits and fat deposition of livestock,it was considered to have significant impact on the milk fat synthesis,fat and edible value.So,through reviewing the biological function and molecular structure of DGAT1 gene as well as the relationship between the polymorphism of DGAT1 gene and various economic traits of livestock,this paper clarified the genetic expression of DGAT1 gene in the development of livestock and made the research prospects of DGAT1 gene in livestock breeding.

关 键 词：家畜 DGAT1 生物学功能 基因多态性 遗传育种 

分 类 号：Q953[生物学—动物学]