试验旨在探究甘油二酯酰基转移酶(diacylglycerol acyltransferase 1,DGAT1)基因g.13504098 C>T位点、核受体辅抑制子1(nuclear receptor subfamily 6 group A member 1,NR6A1)基因g.11204707 A>C位点和α-甘露糖苷酶(alpha-mannosidase...
supported by grants from the National Science&Technology Major Project MKey New Drug Creation and Manufacturing Program,"China(2018ZX09711002-002-007);the Tersonalized Medicines-Molecular Signature-based Drug Discovery and Development/'the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040336);the National Natural Science Foundation of China(81503124,81773791,and 81473262);the Institutes for Drug Discovery and Development Chinese Academy of Sciences(CASIMM0120162025).
Previous studies demonstrated that prolonged exposure to elevated levels of free fatty acids(FFA),especially saturated fatty acids,could lead to pancreaticβ-cell apoptosis,which plays an important role in the progres...